Syncope is an effect of temporal, global hypoperfusion of brain. It is known that even short episodes of circulatory arrest may lead to brain injury. Syncope related repeat hypoperfusion of brain may lead to some impairment of neurocognitive functions in patients with vasovagal syncope (VVS). Aim of study: evaluation of influence of syncope on the neurocognitive functions (NCF) in pts. With suspected VVS. Study population: 185 pts. (131 women) aged 17-70yrs (mean age 40 years), with suspected VVS, referred to HUTT. Methods: All pts. underwent initial evaluation regarding to the number and circumstances of the syncopal and/or presyncopal spells. All pts performed HUTT with Westminster protocol. Basing on the syncope history and HUTT results two groups of pts were recruited: Gr.I - 95 pts with at least 2 syncopal spells and positive HUTT, and gr.II 42 pts with only presyncopal status without complete loss of consciousness and negative HUTT. Pts with only presyncope and positive HUTT were excluded. All pts underwent the evaluation of NCF with computer-assisted Vienna Test System battery produced by Schuhfried (Austria). This batter consisted of the following tests: DAUF- evaluation of long-term selective attention and concentration; COG- assessment of attention and concentration; STROOP- registration of the color-word interference tendency, CORSI – estimation of visual short-term memory capacity and implicite visuo-spatial learning. Values of the measured parameters were compared between both groups of pts. Results: Patients without syncope (gr.II) had higher number of correctly reproduced sequences (11,0 vs 8,38 p < 0,01) and Reliable Spatial Span score (5,50 vs 4,46,p < 0,01) in CORSI test, in relation to pts with syncope (gr. II). This suggests possible influence of the syncope episode on the short-term memory capacity in pts with VVS. There were no significant differences between groups comparing results of the other tests. Conclusions: Repeated syncope episodes may lead to impairment of short-term memory capacity in patients with vasovagal syndrome. Syncope has negative influence on neurocognitive functions in patients with vasovagal syndrome