RETROSPECTIVE ANALYSIS OF AZITHROMYCIN ON THE QT INTERVAL PROLONGATION IN ACUTE CORONARY SYNDROME PATIENTS
D. Lumban Gaol, M. Winardi, R.J. Saragih, S. Salim, S.A. Nasution
1.Department of Internal Medicine, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo National Central Hospital, Jakarta, Indonesia 2. Department of Internal Medicine, Faculty of Medicine, Christian University of Indonesia, Jakarta, Indonesia
Introduction: To evaluate the effect of azithromycin on QT prolongation in acute coronary syndrome (ACS) patients.
Methods: We performed a retrospective cohort study of patients with ACS who treated with azithromycin due to pneumonia in 2012. We also explored other risk factors that may cause QT prolongation. Patients divided into group without risk factors (Group 1) and group with risk factors (Group 2). The QTc was calculated using Bazett’s formula on the first day (QTc1), day 3 (QTc3) and day 5 (QTc5) after administration of azithromycin. We compared QTc prolongation in each group with Wilcoxon signed ranks test.
Results: We found 37 patients treated with azythromycin. In Group 1, QTc1 vs QTc3 and QTc1 vs QTc5 were 482±71 ms vs 460±58.1 ms (p = 0.32), and 482±71 ms vs 461±52 ms (p = 0.18), respectively. In Group 2, QTc1 vs QTc3 and QTc1 vs QTc5 were 456±53 ms vs 492±69 ms (p = 0.03), and 456±53 ms vs 494±71 ms (p = 0.03), respectively.
Conclusions: Azithromycin significantly increase QT interval in ACS patients with risk factors.
