THE ROLE OF BASELINE LEVEL OF SERUM HIGH SENSITIVITY C-REACTIVE PROTEIN IN LONG-TERM RECURRENCE AFTER ABLATIVE THERAPY IN PATIENTS WITH PERSISTENT ATRIAL FIBRILLATION
1W.J. Park, 1Y.J. Choi, 1S.H. Lee, 1D.G. Shin, 2H.S. Park, 2Y.N. Kim, 3M.H. Bae, 3Y.C. Cho, 4Y.S. Lee, 5B.C. Jung
1cardiology department, Yeungnam university hospital, Daegu, Korea, 2cardiology department, Keimyung university hospital, Daegu, Korea, 3cardiology department, Kyungpook national university hospital,Daegu, Korea, 4cardiology department, Daegu catholic university hospital, Daegu, Korea 5 cardiology department, fatima medical centre,Daegu, Korea
background: We evaluated the relationship of serum high-sensitivity chronic reactive protein and the recurrence rate in patients with ablative therapy of persistent atrial fibrillation.
Materials and Methods: From March 2010 to January 2012, 43 patients with first catheter ablation for PeAF. Study population was categorized into 2 groups by baseline hs-CRP level of 0.181 mg/l. The mean follow-up duration was 386±240 days. The recurrence was defined as the presence of any atrial tachyarrhythmia.
Results: higher hs-CRP (n=11) groups had higher CHADS2-VASc score (2.9±2.1 vs. 1.5±1.0, p=0.047). LA diameter was significantly longer (46.7±4.6 mm vs. 42.5±5.6 mm, p=0.033) and E/E’ was higher (14.6±5.6 vs. 9.6±3.0, p=0.03) in higher hs-CRP. The trend of high recurrence rate was observed in higher hs-CRP (54.5% vs. 21.9%, p=0.061). In adjusted model, the higher hs-CRP [Hazard ratio, 5.22; 95% confidence interval (CI), 1.45 to 18.74; p=0.011)] were significant risk factor for the recurrence.
Conclusions: Baseline hs-CRP levels before the first AF ablative therapy had a significant prognostic value in predicting long-term recurrence.
