CURRENT GLOBAL PRACTICE OF ICD TESTING: EVERYONE TO HIS TASTE?!

D. Bastian1, F. Al Kandari2, M. Sepsi3, F. Lorgat4, A. Naik5, H. Mazzetti6, D. Becker7, R. Sweidan8 on behalf of PANORAMA Investigators

1Klinikum Nürnberg - Süd, Nürnberg, Germany. 2Kuwait Cardiac Center, Kuwait. 3University Hospital Brno, Brno, Czech Republic. 4Christiaan Barnard Memorial Hospital, Cape Town, South Africa. 5Care Insititute of Medical Sciences, CIMS hospital, Gujarat India. 6Hospital General de Agudos Juan A. Fernández, Buenos Aires, Argentina. 7Medtronic Germany. 8King Fahd Armed Forces Hospital, Jeddah, Saudi Arabia

Abstract

Introduction: Improved technology, the use for primary prevention of sudden cardiac death and potential risks of defibrillation testing (DT) have caused doubts on the necessity of intraoperative testing with Implantable Cardiac Defibrillators (ICD).
Methods: PANORAMA is a long term, multi-center, prospective, non-randomized observational study. We analyzed the current practice of ICD testing at 100 hospitals across 6 geographical regions. In total 2084 subjects were implanted with an ICD (N=1405) or CRT-D (N=679) between 2005 and 2011.
Results: Overall 51% devices were implanted without testing. DT ranged from 28% (Middle East) to 71 % (South Africa) and decreased over time. In 29 centers all implanted devices were tested, 38 centers tested <50% including 11 centers not testing.
Multivariate logistic regression analysis identified the parameters (table 2) as independent predictors for testing.
Conclusions: There are significant differences between and within global regions in current practice of ICD and CRT-D testing with a large proportion of not tested devices and a general trend to less testing. PANORAMA will follow up the impact of the observed differences on patient’s outcome in the long term.


Table 1: ICD test by region
Total patients 2084 (100%) Patients tested 1020 (49%) Primary Prevention tested 554 (45%) CRT-D tested 214 (32%)
Eastern Europe 534 (26%) 54% 42% 44%
India 125 (6%) 62% 46% 32%
Latin America 211 (10%) 63% 59% 43%
Middle East 634 (30%) 28% 29% 15%
South Africa 119 (6%) 71% 60% 52%
Western Europe 461 (22%) 58% 62% 17%

Table 2: Multivariate logistic regression with endpoint ICD test and regions / CRT forced to stay in the model
Odds ratio (95%CI) VF Induction at Implant (1020 pts) NO VF Induction at Implant (1064 pts)
More Testing
V Lead Position Not Apex 14.9 (10.1-22.0) 300 (66%) 158 (34%)
Impl Physician Cardiologist 3.8 (2.7-5.3) 529 (67%) 264 (33%)
Region: Latin America 2.4 (1.2- 5.1) 132 (63%) 79 (37%)
Region: Eastern Europe 1.8 (1.0-3.2) 286 (54%) 248 (46%)
Region: India 1.6 (0.7-3.6) 77 (62%) 48 (38%)
Region: South Africa 1.6 (0.8-3.3) 84 (71%) 35 (39%)
Gender Male 1.5 (1.1-2.0) 847 (50%) 832 (41%)
Region: Western Europe 1.2 (0.7-2.2) 266 (58%) 195 (48%)
LVEF(%) 1.01 (1.00-1.02) 33.1 (±13.6) 29.4 (±10.9)
Less Testing
Primary Prevention 0.7 (0.5-0.9) 559 (45%) 680 (55%)
History of AF 0.6 (0.4-0.8) 186 (44%) 241 (56%)
Year of Implantation 0.6 (0.6-0.7) 2008.7 (±1.6) 2009.1 (±1.5)
CRT ICD 0.4 (0.3-0.5) 214 (32%) 465 (68%)
Region: Middle East 0.1 (0.0-0.2) 175 (28%) 459 (72%)