Submit Manuscript    >>    Login | Register

Concealed Coronary Atherosclerosis in Idiopathic Paroxysmal Atrial Fibrillation is Associated with Imminent Cardiovascular Diseases

Background Previous research showed a significant difference in the presence of subclinical coronary artery disease (CAD) on cardiac CT angiography (CTA) between patients with idiopathic paroxysmal atrial fibrillation (iAF) versus a matched sinus rhythm population (iSR). Here we present 5-year follow-up data and the consequences of subclinical CAD on baseline CTA on the development of cardiovascular disease in iAF. Methods In 99 iAF patients (who underwent CTA as part of work-up for pulmonary vein isolation) and 221 matched iSR controls (who underwent CTA for CAD assessment), the incidence of hypertension, diabetes and major cardiovascular events (MACCE) during follow-up was obtained. Multivariable Cox regression analysis was used to reveal predictors of incident cardiovascular disease in the iAF group. Results During a follow-up of 68±11 months, over one third of patients developed cardiovascular disease, with no difference between iAF and iSR (log-rank p=0.56), and comparable low rates of MACCE (4.0% vs 5.0%,p=0.71). Within the iAF group, age (HR1.12(1.03–1.20);p=0.006), left atrial diameter (HR1.16(1.03–1.31);p=0.01), Segment Involvement Score (total number of coronary segments with atherosclerotic plaque; HR1.43(1.09–1.89);p=0.01) and the number of calcified plaques on CTA (HR0.53(0.30–0.92);p=0.01) were independent predictors of incident cardiovascular disease. Conclusion Subclinical coronary disease on CTA may be useful to identify the subset of patients with iAF that harbour concealed cardiovascular risk factors and need intensive clinical follow-up to ensure timely initiation of appropriate therapy once CV disease develops, including anticoagulation and vascular prophylactic therapy.

Credits: EAMP Dudink, B Weijs, JGLM Luermans, FECM Peeters, S Altintas, K Vernooy, LAFG Pison, RJ Haest, JA Kragten, BLJH Kietselaer, JE Wildberger, HJGM Crijns

Biosense Webster
event date
Introduction to AFib
Ablation Specialist

View Ablation Specialists