THE IMPACT OF POLYNSATURATED FATTY ACID ON THE RECURRENCE AFTER ABLATIVE THERAPY IN PATIENTS WITH PERSISTENT ATRIAL FIBRILLATION
1W.J. Park, 1Y.J. Choi, 1S.H. Lee, 1D.G. Shin, 2H.S. Park, 2Y.N. Kim, 3M.H. Bae, 3Y.C. Cho, 4Y.S. Lee , 5 B.C.
Jung1cardiology department, Yeungnam university hospital, Daegu, Korea, 2cardiology department, Keimyung university hospital, Daegu, Korea,
3cardiology department, Kyungpook national university hospital, Daegu, Korea, 4cardiology department, Daegu catholic university hospital, Daegu,
Korea 5 cardiology department, Fatima medical centre, Daegu, Korea
Background: The aim of this study is to access if patients treated with PUFAs had lower procedural failure rates compared to an untreated population
Materials and Methods:: From Jan 2009 to June 2011, fifty patients with catheter ablation for PeAF were enrolled. 19 patients with PUFA after ablative therapy and 31 patients without PUFA were enrolled in group 1 and 2. Group 1 continued PUFAs during entire follow-up period
Results: 2 patients in group 1 and 13 patients in group 2 had recurrence of AF. The recurrence rate in group 1 was significantly lower than group 2 (10.5% vs. 41.9%, p=0.026). Other prognostic factors for recurrence were sex, hypertension, prevalence period, and use of beta-blocker before and after ablation in univariates analysis. However, multivariates analysis by cox-regression revealed that the use of PUFAs after ablation of PeAF was not significant predictors of recurrence [Hazard ratio (HR), 0.89; 95% Confidence interval (CI), 0.34 to 5.27; p>0.05].
Conclusions: The role of PUFA in upstream therapy after radiofrequency ablation was not clear in this study. Therefore, larger randomized studies will be needed.
