Abstract. Underlying mechanisms of atrial fibrillation occurrence
and its self-extinguishing remain not completely investigated yet. The role of autonomic
tone and sinoatrial node in the interplay between atrial fibrillation and sinus
rhythm is also not fully understood. The
influence of inflammation as a possible source of arrhythmia and likelihood of
its pharmacologic treatment deserves special attention. These complex issues
are important for better understanding of arrhythmogenesis and rhythm control.
Conceptual reconsiderations through the new insights primarily on the hypothetic
basis may delineate new therapeutic and preventive strategies. The aim of this
analytical review was to reinforce the clinical and laboratory studies regarding
the role of: 1) autonomic tone and sinoatrial node in restitution of sinus
rhythm, 2) new concept of “vibrantly quiescent stroboscopic tuning” as a
matured status of atrial fibrillation being prepared for its abruption by
slight impulse, 3) inflammation in the interplay between atrial fibrillation
and sinus rhythm, 4) anti-inflammation and anti-allergic therapy to prevent and
to treat the arrhythmia.
Abbreviations: AF=atrial
fibrillation; SR=sinus rhythm; SAN=sinoatrial node; VQST=vibrantly quiescent
stroboscopic tuning; BGD= bridging the gap of dispersion
Credits: Petras Stirbys MD, PhD