Fibrillation (AF) is a common postoperative complication after coronary artery
bypass grafting. There is contradictory evidence as to whether pre-operative
statin use lowers the incidence of postoperative AF. This study aimed to assess
whether pre operative statin therapy prevents the post-operative AF.
this retrospective cohort study we used a propensity score–matching analysis to
evaluate the effect of preoperative treatment with statins on postoperative
atrial fibrillation. There were 427 matched pairs of patients. Primary
outcome was the incidence of postoperative AF. Secondary outcomes were 30 day
mortality, stroke, myocardial infarction and length of hospital stay.
incidence of postoperative AF was not different in the statin users compared with
the nonusers (123, 28.1%, versus 127, 29.7%, respectively; p = 0.764). The 30
day mortality (6, 1.4%, versus 8, 1.9%; p = 0.590), stroke (10, 2.3%, versus 8,
1.9%; p = 0.634), Myocardial Infarction (2, 0.5%, versus 0, 0.0%; p = 0.499)
and length of hospital stay in days (11.8 ±
9.0, versus 11.9 ± 9.3; p =
0.544) did not differ significantly between the two groups.
In a propensity-matched cohort of patients
undergoing coronary bypass surgery, we could not demonstrate that preoperative
statins were protective for the development of postoperative atrial
Credits: Anil Paturi, MD; Aman Shukla, MD; George Ebra, Ed.D; Viet Nguyen, DO; Steven Borzak, MD