| Trial Name | Trial Type | Status | Conditions | Intervention | Against | Sponsors |
| Prospective, Multi Centre, International Registry of Male and Female Patients Newly Diagnosed With Atrial Fibrillation (GARFIELD) (web link) | N/A | Recruiting | Permanent Atrial Fibrillation | N/A | N/A | Thrombosis Research Institute |
| NAVISTAR® THERMOCOOL® Catheter for the Treatment of Atrial Fibrillation (web link) | Device | Unknown | "Heart Diseases Arrhythmia Atrial Fibrillation " | NAVISTAR® THERMOCOOL® catheter (Phase III) | N/A | Biosense Webster, Inc. |
| Continued Access Protocol (CAP-AF) (web link) | Device | Active, not recruiting | Atrial Fibrillation | Arctic Front Cardiac Cryoablation System (N/A) | N/A | Medtronic Atrial Fibrillation Solutions |
| Global Study to Assess the Safety and Effectiveness of DU-176b vs Standard Practice of Dosing With Warfarin in Patients With Atrial Fibrillation (EngageAFTIMI48) (web link) | Drug | Active, not recruiting | Stroke | warfarin tablets (Phase III) | DU-176b tablets (high dose regimen) | Daiichi Sankyo Inc. |
| Effect of Empirical Left Atrial Appendage Isolation on Long-term Procedure Outcome in Patients With Persistent or Long-standing Persistent Atrial Fibrillation Undergoing Catheter Ablation (BELIEF) (web link) | Procedure | Recruiting | Persistent Atrial Fibrillation | RFCA of PV and extra-PV triggers, LAA isolation along with the conventional ablation strategy (Phase III) | NA | Texas Cardiac Arrhythmia Research Foundation |
| Short Term Outcomes From Minimally Invasive Surgery for the Treatment of Atrial Fibrillation (web link) | NA | Recruiting | Atrial Fibrillation | NA | NA | Virginia Commonwealth University |
| Spironolactone for Paroxysmal Atrial Fibrillation (web link) | Drug | Recruiting | Atrial Fibrillation | Spironolactone | Placebo | Taichung Veterans General Hospital |
| Atrial Fibrillation Rate Control Therapy Guided By Continuous Ambulatory Monitoring (web link) | Device | Active, not recruiting | Atrial Fibrillation | Mobile Cardiac Outpatient Telemetry | NA | Beth Israel Deaconess Medical Center Cardionet |
| Tailored Treatment of Permanent Atrial Fibrillation (web link) | Procedure | Recruiting | Atrial Fibrillation | Ablation Frontiers Cardiac Ablation SystemDC Cardioversions (Phase III) | NA | Ablation Frontiers |
| Early Detection and Treatment of Esophageal Injury After Catheter Ablation for Atrial Fibrillation (web link) | Procedure | Recruiting | Atrial Fibrillation | Endoscopy in group I (all patients) | NA | University of Oklahoma |
| A Prospective Multi Centre Trial on Bipolar Radiofrequency Ablation of Atrial Fibrillation (web link) | Procedure | Recruiting | Atrial Fibrillation | Bipolar radiofrequency ablation | NA | Norwegian University of Science and Technology St. Olavs Hospital Rikshospitalet-Radiumhospitalet HF Haukeland Sykehus HF Ullevaal University Hospital Regionssykehuset i Tromsø HF Feiringklinikken |
| Concomitant Utilization of Radio Frequency Energy for Atrial Fibrillation (CURE-AF) Study (web link) | Device | Recruiting | Atrial Fibrillation | Surgical RF Ablation utilizing the Cardioblate System (Phase III) | NA | Medtronic Cardiac Surgery |
| Medtronic Concomitant Utilization of Radio Frequency for Atrial Fibrillation CURE-AF/Persistent (web link) | Device | Recruiting | Atrial Fibrillation | Surgical RF Ablation utilizing the Cardioblate System (Phase III) | NA | Medtronic Cardiac Surgery |
| Atrial Fibrillation Ablation Device Comparison Study (web link) | Device | Recruiting | Atrial Fibrillation | AtriCure dry bipolar radiofrequency (RF) clamp (Phase 0) | Boston Scientific FLEX 10 unipolar microwave antenna | Maimonides Medical Center |
| Minimally Invasive Surgical Ablation for Atrial Fibrillation/RESTORE IIB (web link) | Device | Not yet recruiting | Atrial Fibrillation | AtriCure Bipolar System (Phase II) | NA | AtriCure, Inc. |
| Usefulness of Markers to Predict Recurrence of Atrial Fibrillation After Radiofrequency Catheter Ablation (web link) | NA | Active, not recruiting | Atrial Fibrillation | NA | NA | University Hospital, Geneva |
| Atrial Fibrillation Recurrence in Obstructive Sleep Apnea (web link) | Device | Recruiting | Sleep Apnea Obstructive Atrial Fibrillation | continuous positive airway pressure (cpap) | NA | Mayo Clinic ResMed Foundation |
| Studies of Disorders and Mechanisms Related to Atrial Fibrillation Before and After DC-Conversion. (web link) | NA | Recruiting | Atrial Fibrillation | NA | NA | Umeå University |
| Bipolar Radiofrequency Ablation of Atrial Fibrillation (web link) | Device | Recruiting | Atrial Fibrillation | AtriCure Bipolar System (Phase III) | NA | AtriCure, Inc. |
| Cardioversion vs. Catheter Ablation for Persistent Atrial Fibrillation (web link) | Procedure | Recruiting | Atrial Fibrillation | catheter ablation (Phase IV) | external electric cardioversion | Deutsches Herzzentrum Muenchen |
| Curing Atrial Fibrillation in Heart Failure (web link) | Procedure | Recruiting | Chronic Heart Failure Atrial Fibrillation | Pulmonary Vein Isolation | NA | North Glasgow University Hospitals NHS Trust |
| Sole-Therapy Treatment of Atrial Fibrillation (web link) | Device | Active, not recruiting | Atrial Fibrillation | Surgical Ablation using the AtriCure Bipolar System (Phase II) | NA | AtriCure, Inc. |
| Recurrence of Atrial Fibrillation in Patients With Dual-Chamber Pacemakers and Drug Therapy (web link) | NA | Recruiting | Atrial Fibrillation | NA | NA | German Atrial Fibrillation Network Medtronic - Vitatron |
| Omega-Three Fatty Acids for the Prevention of Atrial Fibrillation After Cardiac Surgery (web link) | Drug | Recruiting | Atrial Fibrillation | Omega-3 acid ethyl ester (Phase IV) | NA | University of Iowa The Cleveland Clinic St Luke's Hospital - Mid America Heart Institute Carolinas Healthcare System University of Tennessee Cancer Institute Reliant Pharmaceuticals |
| KONVERT-AF – Relevance of Point in Time for Conversion of Acute Atrial Fibrillation (web link) | Device | Not yet recruiting | Atrial Fibrillation | external electrical cardioversion | NA | German Atrial Fibrillation Network German Federal Ministry of Education and Research |
| Investigation of Genetic Risk of Atrial Fibrillation (web link) | NA | Recruiting | Atrial Fibrillation | NA | NA | Nagoya University |
| The Effect of Low Intensity Exercise on Quality of Life and Hemodynamics in Patients With Permanent Atrial Fibrillation (web link) | Procedure | Recruiting | Atrial Fibrillation | Exercise | NA | University of Texas Southwestern Medical Center |
| First Line Radiofrequency Ablation Versus Antiarrhythmic Drugs for Atrial Fibrillation Treatment (The RAAFT Study) (web link) | Procedure | Recruiting | Atrial Fibrillation | Pulmonary Vein Isolation (Phase III) | Drug: Control Group receives Anti-Arrhythmic Drugs per ACC/AHA 2006 Guidelines for the Management of Patients with AF | Population Health Research Institute Johnson & Johnson |
| Clinical and Economic Consequences of Left Atrial Bipolar Radiofrequency Ablation of Persistent and Permanent Atrial Fibrillation During Cardiac Surgery (web link) | Procedure | Recruiting | Atrial Fibrillation Coronary Artery Disease | Intra-operative bipolar radiofrequency ablation of persistent and permanent atrial fibrillation | NA | Medtronic Bakken Research Center Medtronic |
| Omega 3 Fatty Acids and Atrial Fibrillation (web link) | Dietary Supplement | Recruiting | Atrial Fibrillation | omega 3 fatty acids | placebo | University of Dundee |
| STAR-AF:Substrate Versus Trigger Ablation for Reduction of Atrial Fibrillation Trial (web link) | Procedure | Recruiting | Atrial Fibrillation | ablate AF triggers via PVI (Phase IV) | substrate via CFAEs | St. Jude Medical |
| Prevention of Atrial Fibrillation With ARB After Catheter Ablation (web link) | Drug | Not yet recruiting | Atrial Fibrillation Atrial Flutter | Angiotensin Receptor Blocker (valsartan) (Phase IV) | NA | Queen Elizabeth II Health Sciences Centre |
| A Phase III Superiority Study of Vernakalant vs Amiodarone in Subjects With Recent Onset Atrial Fibrillation (web link) | Drug | Recruiting | Atrial Fibrillation | Vernakalant Injection (Phase III) | Amiodarone Injection: | Cardiome Pharma |
| A Study of the Effectiveness of Anti-Arrhythmic Medications After Atrial Fibrillation Ablation (web link) | Drug | Recruiting | Atrial Fibrillation | propafenone; flecainide; sotalol; dofetilide | Device: Radiofrequency catheter ablation | University of Pennsylvania |
| RF Ablation of Atrial Fibrillation (web link) | Procedure | Recruiting | Atrial Fibrillation | RF catheter ablation (Phase I|Phase II) | NA | C. R. Bard |
| Paroxysmal Atrial Fibrillation: Role of Inflammation, Oxidative Stress Injury and Effect of Statins (web link) | Drug | Recruiting | Atrial Fibrillation | Simvastatin (Phase II) | Placebo | University of Calgary Merck Canada Ltd. Canadian Institutes of Health Research (CIHR) |
| Prevention of Atrial Fibrillation Following Esophagectomy (web link) | Drug | Recruiting | Atrial Fibrillation Esophagectomy | Amiodarone (Phase IV) | NA | Purdue University Indiana University School of Medicine Clarian Health Partners |
| Randomized Trial of Two Different Strategies to Treat Paroxysmal Atrial Fibrillation (web link) | Procedure | Recruiting | Atrial Fibrillation | Pulmonary vein ablation | NA | German Atrial Fibrillation Network Bard Biosense Webster, Inc. St. Jude Medical Medtronic |
| Atrial Fibrillation and the Risk for Neurological Complications (web link) | NA | Recruiting | Atrial Fibrillation | NA | NA | University Hospital Muenster German Federal Ministry of Education and Research |
| EPLERAF-Study: Eplerenone in the Prevention of Atrial Fibrillation Recurrences After Cardioversion (web link) | Drug | Recruiting | Atrial Fibrillation | Eplerenone (Phase II) | Placebo | University Hospital, Saarland University Medical Centre Groningen Pfizer |
| Impact Of Eplerenone On Cardiovascular Outcomes In Patients Post Myocardial Infarction (REMINDER) (web link) | Drug | Recruiting | Myocardial Infarction | Eplerenone (Phase III) | Placebo | Pfizer |
| Influence of Home Monitoring on the Clinical Status of Heart Failure Patients With an Impaired Left Ventricular Function (IN-TIME) (web link) | Device | Active, not recruiting | Ventricular Fibrillation Ventricular Tachycardia Congestive Heart Failure | ICD or CRT-D with Home Monitoring feature deactivated | ICD or CRT-D with Home Monitoring feature activated | Biotronik SE & Co. KG |
| Study of the Wearable Defibrillator in Heart-Failure Patients (SWIFT) (web link) | Device | Recruiting | Heart Failure Ventricular Dysfunction Sudden Death Sudden Cardiac Arrest Ventricular Tachycardia Ventricular Fibrillation | wearable defibrillator (LifeVest) | NA | Zoll Medical Corporation |
| Syncope: Pacing or Recording in the Later Years (Spritely) (web link) | Procedure | Recruiting | Syncope Heart Block Conduction Disorder of the Heart | pacemaker (Phase IV) | implantable loop recorder | Canadian Institutes of Health Research (CIHR) |
| Prevention of Thrombosis Recurrence in Patients With Low Circulating Levels of Antithrombin. (web link) | Drug | Recruiting | Venous Thrombosis | Oral anticoagulation | NA | Federico II University |
| Comparison Between Remote Patient Management and Standard Care in CRT-D and ICD-patients to Assess the Impact on Hospital Length of Stay Because of Heart Failure (ConnectOptiVol) (web link) | Behavioral | Recruiting | Heart Failure Ventricular Tachycardia Cardiac Desynchronization | Device triggered remote telephone contact because of Care Alert | Control Arm | Medtronic Bakken Research Center |
| Optimize RV Follow-up Selective Site Pacing Clinical Trial (web link) | Device | Enrolling by invitation | Cardiac Pacing Artificial Cardiac Pacemaker Artificial | Medtronic or Vitatron Dual-Chamber Pacemaker | Medtronic SelectSecure 3830 Lead | Medtronic Cardiac Rhythm Disease Management |
| Intracardiac CrYoablation for AtrioVentricular Nodal Reentrant Tachycardia (web link) | Device | Not yet recruiting | AVNRT AtrioVentricular Nodal Reentrant Tachycardia SVT Supraventricular Tachycardia Heart Disease | Medtronic Freezor Xtra Cardiac Cryoablation Catheter (Phase III) | NA | Medtronic Atrial Fibrillation Solutions |
| CryoCath Freezor CryoAblation Catheter System (CRYOFACTS) (PS-010) (web link) | Device | Recruiting | Tachycardia Atrioventricular Nodal Reentry | Freezor® Cardiac Cryoablation Catheter CryoConsole System (Phase IV) | NA | Medtronic Atrial Fibrillation Solutions |
| Intravenous Lidocaine and Postoperative Outcomes After Cardiac Surgery (web link) | Drug | Active, not recruiting | Cardiac Surgery; Atrial Fibrillation; Postoperative Confusion | Lidocaine | Placebo | Outcomes Research Consortium |
| Identification of Genomic Predictors of Adverse Events After Cardiac Surgery (web link) | Device | Recruiting | Heart Surgery Genetics Atrial Fibrillation Myocardial Infarction | Transesophageal echocardiography | NA | Brigham and Women's Hospital |
| Telemetric Arrhythmia and Syncope Diagnosis - Evaluation of Arrhythmia Treatment Efficacy Arrhythmias, Cardiac (web link) | Device: | Recruiting | Atrial Fibrillation | " Prolonged telemetric Full Disclosure ECG recording | NA | Institute of Cardiology, Warsaw, Poland |
| TReatment of Atrial Fibrillation With Dual dEfibrillator in Heart Failure Patients (web link) | Device | Active, not recruiting | Heart Failure Congestive | Dual (atrial and ventricular) implantable defibrillator (Phase IV) | NA | Guidant Corporation |
| Bi-Ventricular Pacing in Patients With Atrial Fibrillation and Heart Failure (BIFF-Study) (web link) | Device | Unknown | Heart Failure | InSync III (Phase II) | NA | Umeå University |
| Clinical Study of the CardioFocus Endoscopic Ablation System - Adaptive Contact (CFEAS- AC) for the Treatment of Symptomatic Atrial Fibrillation (web link) | Device | Active, not recruiting | Paroxysmal Atrial Fibrillation (CardioFocus EAS-AC ) | CardioFocus EAS-AC | CardioFocus | |
| Catheter Versus Thoracoscopic Surgical Ablation Strategy in Persistent Atrial Fibrillation (web link) | Procedure | Enrolling by invitation | Persistent Atrial Fibrillation | Thoracoscopically Assisted Surgical Ablation | Catheter Ablation | Royal Brompton & Harefield NHS Foundation Trust |
| A Phase III Study of Apixaban in Patients With Atrial Fibrillation (web link) | Drug | Active, not recruiting | Atrial Fibrillation | Apixaban (Phase III) | Acetylsalicylic Acid (ASA) | Bristol-Myers Squibb |
| SAFE Study - Septal Pacing for Atrial Fibrillation Suppression Evaluation (web link) | Device | Active, not recruiting | Atrial Fibrillation | Pacemaker implantation with RA lead in LAS position | Pacemaker implantation with RA lead in RAA position | St. Jude Medical |
| Low Dose of Diltiazem for Rate Control of Atrial Fibrillation (web link) | Drug | Recruiting | Atrial Fibrillation | low dose diltiazem (Phase IV) | NA | Seoul National University Hospital |
| Clinical Evaluation of Therapy™ Cool Flex Ablation Catheter for the Treatment of Paroxysmal Atrial Fibrillation (web link) | Device | Active, not recruiting | Paroxysmal Atrial Fibrillation (Phase II) | Therapy™ Cool Flex Ablation Catheter | St. Jude Medical | |
| Catheter Ablation Versus Antiarrythmic Drugs for Atrial Fibrillation in China (web link) | Procedure | Recruiting | Atrial Fibrillation | catheter ablation (Phase IV) | Digaoxin,amiodarone,? receptor antagonist, Calcium Antagonists | Wuhan University |
| Evaluate Use of Mangosteen Juice Added to Usual Care in Reducing Risk of Recurrent Atrial Fibrillation (web link) | Drug | Recruiting | Recruiting | mangosteen juice (Phase I) | placebo juice | Mayo Clinic |
| Evaluating the Effectiveness of Fish Oil Supplements at Reducing the Recurrence of Atrial Fibrillation (web link) | Drug | Recruiting | Atrial Fibrillation | Fish oil (Phase IV) | Placebo | National Heart, Lung, and Blood Institute (NHLBI) |
| Mode Evaluation in Sick Sinus Syndrome Trial (MODEST) (web link) | Device | Unknown | Sick Sinus Syndrome | Vitatron T70 DR (Phase IV) | NA | Medtronic BRC |
| Evaluation of the WATCHMAN LAA Closure Device in Patients With Atrial Fibrillation Versus Long Term Warfarin Therapy Stroke (web link) | Device | Recruiting | Atrial Fibrillation | WATCHMAN Device (Phase III) | Warfarin | Atritech |
| Ablation or Surgery for Atrial Fibrillation (AF) Treatment (web link) | Procedure | Recruiting | Atrial Fibrillation | Catheter Ablation | Surgical Ablation | St. Antonius Hospital Hospital Clinic of Barcelona AtriCure, Inc. |
| Efficacy and Safety Study of Catheter Ablation for Atrial Fibrillation (web link) | Procedure | Recruiting | Atrial Fibrillation | catheter ablation (Phase IV) | NA | Wuhan University |
| Changes in Myocardial Perfusion During Chronic Multi Site Biventricular Versus Right Ventricular Apex Pacing in Patients With Normal Left Ventricular Function Undergoing His Bundle Ablation for Drug-refractory Atrial Fibrillation (web link) | Device | Recruiting | Atrial Fibrillation | HIS buldle ablation | NA | R&D Cardiologie |
| Cryptogenic Stroke and Atrial Fibrillation Detection Through Implantable Loop Recorder (ILR)" (CRYPTONITE) (web link) | NA | Recruiting | Atrial Fibrillation Stroke | NA | NA | University of Valencia |
| Studies of the Prevention of Atrial Fibrillation by ALA (web link) | Procedure | Unknown | Atrial Fibrillation; Diet Therapy | ALA rich diet (Phase II) | NA | University of Toronto |
| Low Versus High Dose Magnesium Sulfate in the Early Management of Rapid Atrial Fibrillation (web link) | Drug | Unknown | Atrial Fibrillation | sulfate magnesium (Phase III) | magnesium sulfate | University of Monastir |
| The Maintenance of Human Atrial Fibrillation (web link) | NA | Recruiting | Atrial Fibrillation; Arrhythmias Cardiac | NA | NA | University of California, San Diego |
| Pulmonary Vein (PV) -Isolation: Arrhythmogenic Vein(s) Versus All Veins (web link) | Procedure | Unknown | Atrial Fibrillation | Segmental PV-Isolation of the arrhythmogenic vein(s); (Phase IV ) | NA | Deutsches Herzzentrum Muenchen |
| Study to Determine the Efficacy of Perindopril to Prevent the Recurrence of Atrial Fibrillation in Patients With Essential Hypertension : (web link) | Drug | Unknown | Essential Hypertension; Atrial Fibrillation (Phase IV) | Coversyl (perindopril) | Montreal Heart Institute | |
| Cerebral Embolism (CE) in Catheter Ablation of Atrial Fibrillation (AF) (web link) | Procedure | Enrolling by invitation | Atrial Fibrillation | PVI with PVAC | PVI with Cooled-RF | Leiden University Medical Center |
| Interventional Strategies in Treatment of Atrial Fibrillation: Percutaneous Closure of the Left Atrial Appendage Versus Catheter Ablation (web link) | Procedure | Recruiting | Atrial Fibrillation | Percutaneous closure of LAA | Catheter ablation of AF | Deutsches Herzzentrum Muenchen |
| Line vs. Spot Ablation in Persistent Atrial Fibrillation (web link) | Procedure | Recruiting | Atrial Fibrillation | linear anatomically oriented ablations (Phase IV) | focal electrophysiological oriented ablations | Deutsches Herzzentrum Muenchen |
| The Role of Cardiac Biomarkers in Prediction of Outcome in Atrial Fibrillation Patients Undergoing Catheter Ablation (web link) | Other | Recruiting | Atrial Fibrillation | Inflammatory biomarkers (Phase III) | NA | Texas Cardiac Arrhythmia Research Foundation |
| Evaluation Of New Onset Postoperative Atrial Fibrillation (web link) | Device | Recruiting | New Onset Postoperative Atrial Fibrillation | CorMatrix® ECM™ for Pericardial Closure | No Pericardial Closure | CorMatrix Cardiovascular, Inc |
| Circumferential Versus Ganglionated Plexi Ablation for Atrial Fibrillation (AF) (web link) | Procedure | Unknown | Atrial Fibrillation | GP ablation | PV isolation | Cardiovascular Research Society, Greece |
| Current Clinical Practice in the Management of Atrial Fibrillation in Greece: the MANAGE-AF Study (web link) | NA | Recruiting | Atrial Fibrillation | NA | NA | Hellenic Cardiovascular Research Society |
| A Multicenter Data Registry for Outcomes From Surgical Treatment of Atrial Arrhythmias (web link) | Procedure | Unknown | Atrial Fibrillation | Minimally Invasive Maze Procedure | NA | Virginia Commonwealth University |
| Repeat Ablation Procedure in Patients With Relapse of Atrial Fibrillation (web link) | Procedure | Recruiting | Ablation; Paroxysmal Atrial Fibrillation | Ablation | NA | Deutsches Herzzentrum Muenchen |
| Curing Atrial Fibrillation in Heart Failure (web link) | Procedure | Recruiting | Chronic Heart Failure; Atrial Fibrillation | Pulmonary Vein Isolation | NA | NHS Greater Glasgow and Clyde |
| Dronedarone in Pacemakers Patients With Paroxysmal Atrial Fibrillation (web link) | Drug | Not yet recruiting | Paroxysmal Atrial Fibrillation | Dronedarone (Phase IV) | Placebo | Eastbourne General Hospital |
| Impact Of Eplerenone On Cardiovascular Outcomes In Patients Post Myocardial Infarction (web link) | Drug | Recruiting | Myocardial Infarction | Eplerenone (Phase III) | Placebo | Pfizer |
| Influence of Home Monitoring on the Clinical Status of Heart Failure Patients With an Impaired Left Ventricular Function (web link) | Device | Active, not recruiting | Ventricular Fibrillation; Ventricular Tachycardia; Congestive Heart Failure | ICD or CRT-D with Home Monitoring feature deactivated; (Phase IV) | ICD or CRT-D with Home Monitoring feature activated | Biotronik SE & Co. KG |
| MINERVA: MINimizE Right Ventricular Pacing to Prevent Atrial Fibrillation and Heart Failure (web link) | Device | Recruiting | Atrial Fibrillation Heart Failure Congestive | Pacemaker Medtronic EnRhythm (Phase IV) | NA | Medtronic Bakken Research Center |
| Influence of Home Monitoring on the Clinical Status of Heart Failure Patients With an Impaired Left Ventricular Function (web link) | Device | Active, not recruiting | Ventricular Fibrillation; Ventricular Tachycardia; Congestive Heart Failure | ICD or CRT-D with Home Monitoring feature deactivated; (Phase IV) | ICD or CRT-D with Home Monitoring feature activated | ICD or CRT-D with Home Monitoring feature activated |
| Study of the Wearable Defibrillator in Heart-Failure Patients (web link) | Device | Recruiting | Heart Failure; Ventricular Dysfunction; Sudden Death; Sudden Cardiac Arrest; Ventricular Tachycardia; Ventricular Fibrillation | wearable defibrillator (LifeVest) | NA | Zoll Medical Corporation |
| Syncope: Pacing or Recording in the Later Years (web link) | Procedure | Recruiting | Syncope; Heart Block; Conduction Disorder of the Heart | pacemaker (Phase IV) | implantable loop recorder | Canadian Institutes of Health Research (CIHR) |
| Prevention of Thrombosis Recurrence in Patients With Low Circulating Levels of Antithrombin (web link) | Drug | Recruiting | Venous Thrombosis | Oral anticoagulation | NA | Federico II University |
| Comparison Between Remote Patient Management and Standard Care in CRT-D and ICD-patients to Assess the Impact on Hospital Length of Stay Because of Heart Failure (web link) | Behavioral | Recruiting | Heart Failure; Ventricular Tachycardia; Cardiac Desynchronization | Device triggered remote telephone contact because of Care Alert | Control Arm | Medtronic Bakken Research Center |
| Optimize RV Follow-up Selective Site Pacing Clinical Trial (web link) | Device | Enrolling by invitation | Cardiac Pacing Artificial; Cardiac Pacemaker Artificial | Medtronic or Vitatron Dual-Chamber Pacemaker | NA | Medtronic Cardiac Rhythm Disease Management |
| Intracardiac CrYoablation for AtrioVentricular Nodal Reentrant Tachycardia (web link) | Device | Not yet recruiting | AVNRT; AtrioVentricular Nodal Reentrant Tachycardia; SVT; Supraventricular Tachycardia; Heart Disease | Medtronic Freezor Xtra Cardiac Cryoablation Catheter (Phase III) | NA | Medtronic Atrial Fibrillation Solutions |
| Intracardiac CrYoablation for AtrioVentricular Nodal Reentrant Tachycardia (web link) | Device | Not yet recruiting | AVNRT; AtrioVentricular Nodal Reentrant Tachycardia; SVT; Supraventricular Tachycardia; Heart Disease | Medtronic Freezor Xtra Cardiac Cryoablation Catheter (Phase III) | NA | Medtronic Atrial Fibrillation Solutions |
| CryoCath Freezor CryoAblation Catheter System (CRYOFACTS) (web link) | Device | Recruiting | Tachycardia Atrioventricular Nodal Reentry | Freezor® Cardiac Cryoablation Catheter CryoConsole System (Phase IV) | NA | Medtronic Atrial Fibrillation Solutions |
| Neuropsychological Cognitive Behavioral Therapy for Patients With Acquired Brain Injury (web link) | Behavioral | Recruiting | Brain Injury | Neuropsychological Cognitive Behavioral Therapy (Phase II) | NA | Philipps University Marburg Medical Center |
| Effect of Glycemic Variability on Autonomic Tone in Hospitalized Patients With Type 2 Diabetes (web link) | Drug | Recruiting | Type 2 Diabetes; Inpatient | Intravenous insulin (Phase IV) | Subcutaneous Insulin | Ohio State University |
| Identification of Genetic, Biochemical and Hormonal Factors Contributing to Atrial Fibrillation (web link) | NA | Recruiting | Atrial Fibrillation | NA | NA | The Cleveland Clinic |
| Optimized Heart Failure Therapy Through Continuous Monitoring (web link) | Device | Recruiting | Heart Failure | implantation implantable loop recorder Medtronic reveal XT Full view | NA | Kennemer Gasthuis |
| Continuous Positive Airway Pressure Treatment of Obstructive Sleep Apnea to Prevent Cardiovascular Disease (web link) | Device | Recruiting | Sleep Apnea; Cardiovascular Disease | Continuous Positive Airway Pressure (CPAP) | Standard care | Adelaide Institute for Sleep Health |
| On-Pump vs. Off-Pump CABG in High-Risk Patients (EuroSCORE 6+) I (web link) | Procedure | Enrolling by invitation | schemic Heart Disease; Post-Operative Complications | OPCAB - the off-pump coronary artery bypass | NA | Charles University, Czech Republic |
| An-Art Study: Atrioventricular (AV) Node Ablation in Cardiac Resynchronisation Therapy (web link) | Procedure | Unknown | Congestive Heart Failure | AV-node ablation | NA | University Hospital, Basel, Switzerland |
| Multicentre Retrospective Study to Understand Anti-thrombotic Treatment Patterns and Outcomes of Acute Coronary Syndrome (ACS) Patients (web link) | NA | Recruiting | Acute Coronary Syndrome | NA | NA | AstraZeneca |
| Investigation Drug-drug Interaction Between Dabigatran and Clarithromycin (web link) | Drug | Active, not recruiting | Healthy | Dabigatran then dabigatran and clarithromycin (Phase I) | Clarithromycin and dabigatran then dabigatran | Centre Hospitalier Universitaire de Saint Etienne |
| Effects of Angiotensin II Receptor Blocker Compared With Diuretics in High-risk Hypertensive Patients (web link) | Drug | Recruiting | Essential Hypertension | Amlodipine, Telmisartan, compound Amiloride, Simvastatin (Phase IV) | NA | Cardiovascular Institute & Fuwai Hospital |
| A Personalized Dashboard to Educate Veterans at Risk of Stroke (web link) | Behavioral | Active, not recruiting | Cardiovascular Disease Stroke | Risk Factor Counseling | Risk Factor Counseling Plus Computerized Dashboard | Department of Veterans Affairs |
| Collaborative Systematic Overview of Randomised Controlled Trials of Beta-Blockers in the Treatment of Heart Failure (web link) | Drug | Enrolling by invitation | Heart Failure | Beta blocker | Placebo | Royal Brompton & Harefield NHS Foundation Trust |
| Influence of Home Monitoring on the Clinical Status of Heart Failure Patients With an Impaired Left Ventricular Function (web link) | Device | Recruiting | Ventricular Fibrillation Ventricular Tachycardia Symptomatic Heart Failure | ICD or CRT-D with Home Monitoring feature deactivated (Phase IV) | ICD or CRT-D with Home Monitoring feature activated | Biotronik GmbH & Co. KG |
| Concomitant Treatment of Permanent Atrial Fibrillation (web link) | Device | Active, not recruiting | Atrial Fibrillation | Surgical bipolar radiofrequency ablation using the AtriCure Bipolar System (Phase III) | NA | AtriCure, Inc. |
| Neuropsychological Cognitive Behavioral Therapy for Patients With Acquired Brain Injury (web link) | Behavioral | Recruiting | Brain Injury | Neuropsychological Cognitive Behavioral Therapy (Phase II) | NA | Philipps University Marburg Medical Center Psychotherapie-Ambulanz Marburg e.V. |
| On-Pump vs. Off-Pump CABG in High-Risk Patients (EuroSCORE 6+) (web link) | Procedure | Enrolling by invitation | Ischemic Heart Disease Post-Operative Complications | OPCAB - the off-pump coronary artery bypass | NA | Charles University, Czech Republic |
| An-Art Study: Atrioventricular (AV) Node Ablation in Cardiac Resynchronisation Therapy (web link) | Procedure | Recruiting | Congestive Heart Failure | AV-node ablation | NA | University Hospital, Basel, Switzerland |
| An Efficacy and Safety Study for Nesiritide in Heart Failure Patients With Reduced Kidney Function Undergoing Coronary Artery Bypass Graft Surgery Requiring Cardiopulmonary Bypass (CPB Pump or Heart Lung Machine) (web link) | Drug | Withdrawn | Coronary Artery Bypass Surgery Ischemic Heart Disease Heart Failure Congestive Coronary Artery Bypass Grafting Coronary Heart Disease Cardiopulmonary Bypass | Nesiritide (Phase III) | NA | Scios, Inc. |
| Efficacy of Different Ablation Strategies for Controlling Atrial Fibrillation (web link) | Procedure | Recruiting | Atrial Fibrillation | Radiofrequency ablation | NA | University of Pennsylvania |
| The BENEFIT Trial: Evaluation of the Use of an Antiparasital Drug (Benznidazole) in the Treatment of Chronic Chagas' Disease (web link) | Drug | Recruiting | Chagas Disease Trypanosomiasis Heart Disease | Benznidazole (Phase III) | NA | Hamilton Health Sciences Dante Pazzanese Institute, Brazil Hospital das Clinicas de Ribeirao Preto/USP World Health Organization |
| PreFER Managed Ventricular Pacing (MVP) For Elective Replacement (web link) | Device | Recruiting | Cardiovascular Diseases | Feature MVP programmed ON/OFF (Phase IV) | NA | Medtronic Bakken Research Center Medtronic |
| Combination of OLMesartan and CCB or Low Dose Diuretics in High Risk Elderly Hypertensive Patients Study (COLM-Study) (web link) | Drug | Recruiting | Hypertension Cardiovascular Disease Diabetes | Olmesartan medoxomil (Phase IV) | Calcium channel blockers (amlodipine, azelnidipine) | COLM Study Research Organization Japan Heart Foundation |
| Effectiveness of Combining Beta-Blocker Therapy and a Pacemaker Following a Heart Attack (The PACE-MI Trial) (web link) | Device | Recruiting | Myocardial Infarction Bradycardia Heart Block | Implantable Pacemaker | Drug: Metoprolol (Beta-Blocker Medication) | National Heart, Lung, and Blood Institute (NHLBI) |
| Statin Therapy in Heart Failure: Potential Mechanisms of Benefit (web link) | Drug | Recruiting | Heart Failure Congestive | Atorvastatin (Phase IV) | NA | University of California, Los Angeles Pfizer |
| Obstructive Sleep Apnea and Stroke (web link) | Other | Recruiting | Stroke Obstructive Sleep Apnea | polygraphic study | NA | University Hospital, Bordeaux |
| Utility of Clinical Examination in the Noninvasive Prediction of Aortic Atheroma - A Prospective Study (web link) | Procedure | Recruiting | Aortic Atheroma | transthoracic examination | NA | Creighton University |
| Evaluation of the SafeR Mode in Patients With a Dual Chamber Pacemaker Indication (web link) | Device | Recruiting | Assess the Benefits From the AAISafeR/SafeR Algorithm of Symphony 2550 or REPLYTM DR in a Wide Range of Pacemaker Patients. | Symphony DR 2550 and REPLY DR cardiac pacemakers (Phase IV) | Symphony DR 2550 and REPLY DR cardiac pacemakers | Sorin Group |
| POISE Trial: Perioperative Ischemic Evaluation Study (web link) | Drug | Terminated | Cardiovascular Diseases | Metoprolol controlled release (CR) (Phase III) | Placebo | Hamilton Health Sciences Canadian Institutes of Health Research (CIHR) National Health and Medical Research Council, Australia British Heart Foundation AstraZeneca |
| Radiofrequency Ablation of Drivers of Atrial Fibrillation (web link) | Procedure | Not yet recruiting | Atrial Fibrillation | Radiofrequency catheter ablation (Phase III) | NA | Hospital General Universitario Gregorio Marañon Centro Nacional de Investigación Cardiovascular (CNIC) |
| Evaluation of Efficacy and Safety of Omacor (Omega-3-Acid Ethyl Esters) in Recurrent, Symptomatic Atrial Fibrillation (web link) | Drug | Recruiting | Atrial Fibrillation | Omega-3-acid ethyl esters (Phase III) | placebo corn oil | GlaxoSmithKline Reliant Pharmaceuticals |
| Comparison of Valsartan With Amlodipine in Hypertensive Patients With Glucose Intolerance (web link) | Drug | Recruiting | Hypertension Type 2 Diabetes Mellitus | Valsartan (Phase IV) | Amlodipine | Nagoya University |
| Study to Verify Proper Detection of Supraventricular Tachyarrhythmia With Single-Lead Dual-Chamber Implantable Cardioverter-Defibrillators (ADRIA) (web link) | Device | Active, not recruiting | Tachyarrhythmia | Implantable cardioverter-defibrillator (Phase IV) | NA | Biotronik GmbH & Co. KG |
| Effectiveness of Pacemaker With Closed Loop Stimulation Compared to Pacemakers With and Without Standard Rate Response (web link) | Device | Recruiting | Bradycardia | Pacemaker (Phase IV) | NA | Biotronik, Inc. |
| Best Bypass Surgery (BBS) Trial (web link) | Procedure | Active, not recruiting | Heart Disease Cardiovascular Disease | Coronary artery bypass grafting (Phase III) | NA | Rigshospitalet, Denmark Danish Heart Foundation The Danish Medical Research Council Copenhagen Hospital Corporation |
| APART: Prevention and Automatic Therapy of Atrial Arrhythmias in Patients With Paroxysmal Supraventricular Tachycardias (web link) | Device | Recruiting | Tachyarrhythmia | Activation of preventive and therapeutic atrial algorithms (Phase IV) | NA | Medtronic Bakken Research Center Medtronic |
| Levosimendan in Acute Heart Failure Following Acute Myocardial Infarction. (web link) | Drug | Recruiting | Myocardial Infarction Heart Failure Cardiogenic Shock | levosimendan (drug) (Phase IV) | NA | Ullevaal University Hospital |
| Supplemental Benefit of ARB in Hypertensive Patients With Stable Heart Failure Using Olmesartan (SUPPORT Trial) (web link) | Drug | Recruiting | Chronic Heart Failure | olmesartan medoxomil (Phase III) | NA | Tohoku University |
| Valsartan in Cardiovascular Disease With Renal Dysfunction (The V-CARD) Study (web link) | Drug | Recruiting | Hypertension | valsartan 40 or 160 (80) mg per day (Phase IV) | NA | Kumamoto University |
| Steroids In caRdiac Surgery Trial (SIRS Trial) (web link) | Drug | Recruiting | Cardiac Surgical Procedures Cardiopulmonary Bypass Systemic Inflammatory Response Syndrome | Methylprednisolone (Phase III) | NA | Hamilton Health Sciences Population Health Research Institute International Clinical Epidemiology Network (INCLEN) TRUST |
| Organization in Acute Atrial Fibrillation Post Open Heart Surgery (web link) | NA | Enrolling by invitation | Atrial Fibrillation | NA | NA | State University of New York - Upstate Medical University |
| Glutamate for Metabolic Intervention in Coronary Surgery (web link) | Drug | Recruiting | Coronary Artery Bypass Myocardial Ischemia Myocardial Infarction Coronary Artery Disease | Intravenous infusion of 0.125 M glutamic acid solution (Phase III) | NA | University Hospital, Linkoeping University Hospital Orebro Blekingesjukhuset, Karlskrona |
| Warfarin Versus Aspirin in Reduced Cardiac Ejection Fraction (WARCEF) Trial (web link) | Drug | Recruiting | Heart Disease Stroke Ischemic Heart Disease Myocardial Infarction | aspirin (Phase III) | Warfarin | Columbia University National Institute of Neurological Disorders and Stroke (NINDS) |
| PANORAMA Observational Study (web link) | Device | Recruiting | Arrhythmia Cardiac Pacemaker Artificial Defibrillators Implantable | Cardiac Pacemaker, Defibrillator, pacemaker lead (Phase IV) | NA | Medtronic Bakken Research Center |
| PROTECT-PACE STUDY - The Protection of Left Ventricular Function During Right Ventricular Pacing (web link) | Device | Not yet recruiting | Left Ventricular Dysfunction | Pacing lead position | NA | Medtronic Cardiac Rhythm Disease Management Medtronic |
| Prevention Of Recurrence Of Atrial Fibrillation (web link) | Drug | Active, not recruiting | Atrial Fibrillation | SB-207266 (Phase II) | NA | GlaxoSmithKline |
| DATAS: The Dual Chamber & Atrial Tachyarrhythmias Adverse Events Study (web link) | Device | Active, not recruiting | Implantable Cardioverter-Defibrillators Tachycardia Ventricular Ventricular Fibrillation | Implantable Cardioverter Defibrillator (Phase IV) | NA | Medtronic Bakken Research Center |
| Biopace Study: Biventricular Pacing for Atrioventricular Block to Prevent Cardiac Desynchronization (web link) | Device | Recruiting | Atrioventricular Block Ventricular Dysfunction | Standard right ventricular (RV) pacing vs CRTP | NA | St. Jude Medical |
| Right Apical Versus Septal Pacing Trial (web link) | Device | Recruiting | Heart Block Heart Failure | Permanent Pacemaker Implantation | NA | Lawson Health Research Institute Medtronic |
| The Danish Multicenter Randomised Study on AAI Versus DDD Pacing in Sick Sinus Syndrome (web link) | Device | Recruiting | Sick Sinus Syndrome | AAIR/DDDR pacemaker (Phase II|Phase III) | NA | The DANPACE investigator group |
| NT-proBNP for Diagnosis and Resource Utilization in Patients With Acute Dyspnoea (web link) | NA | Recruiting | Heart Failure Edema | NA | NA | University Hospital Mannheim |
| TRADE HF (TReatment of Atrial Fibrillation With Dual dEfibrillator in Heart Failure Patients) (web link) | Device | Recruiting | Heart Failure Congestive | Renewal 4 AVT (Phase IV) | NA | Guidant Corporation |
| The Use of Remote Magnetic Navigation in Catheter Ablation of Heart Arrythmia (web link) | Procedure | Recruiting | Arrythmia | Catheter ablation using the Stereotaxis equipment | NA | Rigshospitalet, Denmark |
| EnTRINSIC - EnPulse Trial on Search AV+ Influence (web link) | Device | Terminated | Arrhythmia Sinus | Search AV+ algorithm (Phase IV) | NA | Medtronic Bakken Research Center Medtronic |
| Cerebral Artery Stenosis, Coronary Artery Disease and Arrhythmia (web link) | Procedure | Recruiting | Stroke Coronary Artery Disease Arrhythmia | Digital subtraction angiography and 24-hour simultaneous recorder of electrocardiograph (Phase IV) | NA | Far Eastern Memorial Hospital |
| PERIOP 2 - A Safety and Effectiveness Study of LMWH Bridging Therapy Versus Placebo Bridging Therapy for Patients on Long Term Warfarin and Require Temporary Interruption of Their Warfarin. (web link) | Drug | Recruiting | Stroke | Dalteparin (Phase III) | NA | Lawson Health Research Institute Canadian Institutes of Health Research (CIHR) Pfizer |
| Clinical Investigation of the Medtronic Concerto™ Device (web link) | Device | Active, not recruiting | Congestive Heart Failure Atrial Arrhythmia Atrial Tachyarrhythmia Atrial Fibrillation | Cardiac Resynchronization Therapy+Implantable Cardioverter Defibrillator | NA | Medtronic Cardiac Rhythm Disease Management |
| Closed Loop Stimulation, Cognitive Performance, and Quality of Life in Pacemaker Patients (web link) | Device | Recruiting | Cardiac Pacing Artificial Quality of Life | Rate-adaptive pacemaker: accelerometer (Phase IV) | Rate-adaptive pacemaker: Closed Loop Stimulation | Biotronik GmbH & Co. KG |
| Rapid Diagnosis of Myocardial Damage and Coronary Stenosis With MRI (web link) | NA | Active, not recruiting | Myocardial Infarction | NA | NA | University Hospital, Linkoeping Jonkoping County Hospital The Medical Research Council of Southeast Sweden |
| The Effect of Reduced Dose of Enoxaparin on the Outcomes of Treatment With Enoxaparin (web link) | NA | Recruiting | Acute Coronary Syndrome Venous Thromboembolism Atrial Fibrillation Hypercoagulability | NA | NA | Hadassah Medical Organization |
| The Home INR Study (THINRS) (web link) | Procedure | Active, not recruiting | Atrial Fibrillation | Weekly patient self-testing of prothrombin time (Phase IV) | NA | Department of Veterans Affairs VA CSP |
| Study to Find Out the Appropriate Initial Dose of the Anticoagulant Drug Phenprocoumon (web link) | Other | Recruiting | Pulmonary Embolism Atrial Fibrillation Orthopedic Surgery Prophylaxis | Algorithm for phenprocoumon (Phase IV) | algorithm for phenprocoumon | Cantonal Hospital of St. Gallen |
| Comparison of Warfarin Dosing Using Decision Model vs. Pharmacogenetic Algorithm (web link) | Drug | Recruiting | Atrial Fibrillation Pulmonary Embolism Deep Vein Thrombosis | warfarin (Phase IV) | NA | Creighton University |
| After Discharge Management of Low Income Frail Elderly (web link) | Behavioral | Recruiting | Heart Failure Congestive Coronary Arteriosclerosis Atrial Fibrillation Cerebrovascular Accident Pulmonary Disease Chronic Obstructive Diabetes Mellitus Hypertension Osteoarthritis Osteoporosis | Behavioral | behavioral | Summa Health System |
| Pivotal Clinical Study of Endoscopic Ablation for Atrial Fibrillation (AF) in Patients That Have Failed Drugs (web link) | Procedure | Suspended | Atrial Fibrillation | Single ablation procedure with Endoscopic Ablation System (Phase III) | NA | CardioFocus |
| Modeling Genotype and Other Factors to Enhance the Safety of Coumadin Prescribing (web link) | Drug | Not yet recruiting | Atrial Fibrillation Deep Venous Thrombosis Heart Valve Replacement Pulmonary Embolism | Coumadin | NA | Agency for Healthcare Research and Quality (AHRQ) Marshfield Clinic Research Foundation |
| Genetic Determinants of Warfarin Anticoagulation Effect (web link) | Drug | Recruiting | Venous Thrombosis Pulmonary Embolism Atrial Fibrillation | Warfarin | NA | Hadassah Medical Organization Israel Binational Science Foundation, United States Israel Science Foundation Ministry of Health, Israel |
| Pharmacodynamic Drug Interaction Between Warfarin and Amoxicillin-Clavulanic Acid (web link) | Drug | Not yet recruiting | Oral Anticoagulation Deep Venous Thrombosis Atrial Fibrillation Pulmonary Embolism | Firstly : Amoxicillin-Clavulanic acid and secondly : Placebo (Phase IV) | Firstly : Placebo and secondly : Amoxicillin-Clavulanic acid | Assistance Publique - Hôpitaux de Paris GlaxoSmithKline |
| Study to Develop a Reliable Nomogram That Incorporates Clinical and Genetic Information (web link) | Drug | Recruiting | Pulmonary Embolism Deep Vein Thrombosis Atrial Fibrillation | Warfarin | NA | Brigham and Women's Hospital Massachusetts General Hospital Newton-Wellesley Hospital North Shore Medical Center Faulkner Hospital Spaulding Rehabilitation Hospital |
| Testing Strategies to Improving Warfarin Adherence (web link) | Behavioral | Recruiting | Atrial Fibrillation Deep Venous Thrombosis Dilated Cardiomyopathies | Lottery arm (Lottery and Med-eMonitor) | Non-Lottery (Med-eMonitor only) | University of Pennsylvania Aetna, Inc. |
| Guidant Microwave Ablation System for the Treatment of Atrial Fibrillation (web link) | Device | Terminated | Atrial Fibrillation | Flex 4 and Generator (Phase III) | NA | Guidant Corporation |
| CONNECT Study - Clinical Evaluation Of Remote NotificatioN to rEduCe Time to Clinical Decision (web link) | Device | Active, not recruiting | Arrhythmia Tachycardia Atrial Fibrillation Ventricular Fibrillation | Remote Management | In-Office Care | Medtronic Cardiac Rhythm Disease Management Medtronic Symbios Clinical |
| Medtronic Genetic Arrhythmia Markers for Early Detection (GAME Study) (web link) | NA | Recruiting | Death Sudden Cardiac Ventricular Fibrillation Tachycardia Atrial Fibrillation Sick Sinus Syndrome | NA | NA | Medtronic Corporate Technologies and New Ventures |
| Routine Mini-Invasive Electrophysiology Study for Patients Feeling Tachycardia, With a Negative Holter ECG (web link) | Procedure | Recruiting | Pre-Excitation Syndromes Paroxysmal Tachycardia Atrial Fibrillation Atrial Flutter Wolff-Parkinson-White Syndrome | Mini-invasive electrophysiological study | NA | Sykehuset Telemark Rikshospitalet-Radiumhospitalet HF |
| The IMPACT of BIOTRONIK Home Monitoring Guided Anticoagulation on Stroke Risk in Patients With Implanted ICD and CRT-D Devices (web link) | Drug | Recruiting | Atrial Fibrillation Atrial Flutter Stroke Systemic Embolism Major Bleeding | warfarin, according to a predefined anticoagulation plan (Phase IV) | warfarin, physician-directed based on conventional criteria | Biotronik, Inc. |
| Effect of Angiotensin II Receptor Blockers (ARB) on Left Ventricular Reverse Remodelling After Aortic Valve Replacement in Severe Valvular Aortic Stenosis (web link) | Drug | Recruiting | Aortic Valve Stenosis Left Ventricular Hypertrophy Atrial Fibrillation | Candesartan (Phase III) | NA | Odense University Hospital |
| Avoid FFS - Use of the Atrial Pacemaker Lead 1699 With Very Short Tip Ring Spacing to Avoid Far Field Sensing (web link) | Device | Recruiting | Atrial Fibrillation Bradycardia | pacemaker implantation (Phase IV) | NA | St. Jude Medical |
| MPAACS: Magnesium for the Prevention of Atrial Arrhythmias After Cardiac Surgery (web link) | Drug | Recruiting | Ischemic or Valvular Heart Disease Requiring Surgery | intravenous magnesium (Phase III) | NA | University of British Columbia Heart and Stroke Foundation of BC and Yukon |
| The IMPACT of BIOTRONIK Home Monitoring Guided Anticoagulation on Stroke Risk in Patients With Implanted ICD and CRT-D Devices (web link) | Drug | Recruiting | Atrial Fibrillation; Atrial Flutter; Stroke; Embolism Systemic Arterial; Major Bleeding | : Oral Anticoagulation (dabigatran etexilate, warfarin) | NA | Biotronik, Inc. |
| Atrial Fibrillation Management in Congestive Heart Failure With Ablation (web link) | Device | Recruiting | Atrial Fibrillation | ICD/CRT implant | AF ablation | St. Jude Medical |
| A Pharmacogenetic Study of Warfarin Dosing, The COUMA-GEN Study (web link) | Drug | Recruiting | Atrial Fibrillation Deep Vein Thrombosis Pulmonary Embolism | Standard of care or genotyping dosing of warfarin dosing | NA | Intermountain Health Care, Inc. Deseret Foundation LDS Hospital Cardiovascular Research |
| Routine Mini-Invasive Electrophysiology Study for Patients Feeling Tachycardia, With a Negative Holter ECG Procedure: Mini-invasive electrophysiological study (web link) | Procedure | Unknown | Pre-Excitation Syndromes Paroxysmal Tachycardia Atrial Fibrillation Atrial Flutter Wolff-Parkinson-White Syndrome | Mini-invasive electrophysiological study | NA | Sykehuset Telemark |
| Inhaled Sevoflurane Compared to Intravenous Sedation Post Coronary Artery Bypass Grafting (web link) | Drug | Recruiting | Myocardial Reperfusion Injury Atrial Fibrillation | Sevoflurane (Phase I|Phase II) | NA | Karolinska Institutet |
| Effect of Angiotensin II Receptor Blockers (ARB) on Left Ventricular Reverse Remodelling After Aortic Valve Replacement in Severe Valvular Aortic Stenosis (web link) | Drug | Unknown | Aortic Valve Stenosis Left Ventricular Hypertrophy Atrial Fibrillation | Candesartan | NA | Odense University Hospital |
| Change of Heart Rate Variability and Baroreflex Sensitivity After Ventral Cardiac Denervation (web link) | Procedure | Not yet recruiting | Atrial Fibrillation | ventral cardiac denervation | NA | Far Eastern Memorial Hospital |
| Capsule Endoscopy for Post-Ablation Esophageal Lesion Assessment (CEPELA) (web link) | Device | Recruiting | Esophageal Lesion | PillCam ESO Capsule Endoscope | NA | The Cleveland Clinic |
| ALA and Prostate Cancer (web link) | Procedure | Active, not recruiting | Atrial Fibrillation Diet Therapy Prostate Cancer | ALA-rich diet (Phase II) | NA | University of Toronto |
| Detection of Left Atrial Appendage (LAA) Thrombus: Comparison of Cardiac Magnetic Resonance Imaging and Transesophageal Echocardiogram (web link) | NA | Unknown | Left Atrial Appendage Thrombi | NA | NA | Gundersen Lutheran Medical Foundation |
| DISCOVERY: Diagnostic Data and Genetic Polymorphisms in ICD Patients. (web link) | Device | Recruiting | Death Sudden Cardiac Ventricular Fibrillation Tachycardia Atrial Fibrillation Sick Sinus Syndrome | Defibrillator, Dual Chamber ; Implantable (Phase IV) | Procedure: Blood sampling | Medtronic Bakken Research Center |
| Impact of Ascorbic Acid on Post-Cardiothoracic Surgery Inflammation (AFIST) (web link) | Drug | Unknown | Cardiac Surgery Inflammation | Ascorbic acid | Placebo | Hartford Hospital |
| Dual Chamber Versus Single Chamber Cardiac Pacing in People 80 Years of Age and Older (web link) | Device | Recruiting | Atrial Fibrillation Cardiac Pacing Artificial | Dual chamber cardiac pacemaker | Single chamber cardiac pacemaker | University of Calgary Calgary Health Trust |
| Optimal Sensing in Atrial Tachyarrhythmia's Study (web link) | Device | Recruiting | Sick Sinus Syndrome | Accent Pacemaker | Paroxysmal Atrial Fibrillation | St. Jude Medical |
| The Impact of Short-Term High Intensity Statin Therapy on Post-Operative Inflammatory Markers (web link) | Drug | Recruiting | Cardiac Surgery Inflammation | Atorvastatin, high intensity (Phase IV) | Atorvastatin, low intensity | Hartford Hospital The Gustavus and Louise Pfeiffer Research Foundation |
| Change of Heart Rate Variability and Baroreflex Sensitivity After Ventral Cardiac Denervation (web link) | Procedure | Unknown | Atrial Fibrillation | ventral cardiac denervation | NA | Far Eastern Memorial Hospital |
| Evaluation of Depolarization and Repolarisation Activity During Cardiac Arrhythmia Using a Novel Monophasic Action Potential Catheter (web link) | Device | Recruiting | Atrial Fibrillation
Ventricular Fibrillation
Tachycardia Ectopic Junctional | Cardiac chambers mapping with MAP 4 | NA | University Hospital, Bordeaux |
| Pharmacogenetics and Cardiovascular Events (web link) | NA | Active, not recruiting | Cardiovascular Diseases Atrial Fibrillation Cerebrovascular Accident Heart Diseases Myocardial Infarction | NA | NA | National Heart, Lung, and Blood Institute (NHLBI) |
| Effectiveness of Bridging Anticoagulation for Surgery (The BRIDGE Study) (web link) | Drug | Recruiting | Arterial Thromboembolic Events Atrial Fibrillation | Placebo (Phase III) | Dalteparin | National Heart, Lung, and Blood Institute (NHLBI) |
| Irrigated Ablation System Evaluation for AF (web link) | Device | Recruiting | Paroxysmal Atrial Fibrillation | SJM Irrigated Cardiac Ablation System | FDA approved Open Irrigated RF Ablation System | St. Jude Medical |
| Catheter Ablation Versus Standard Conventional Treatment in Heart Failure Patients With Atrial Fibrillation (web link) | Procedure | Recruiting | Atrial Fibrillation Heart Failure | Radiofrequency ablation (Phase IV) | Other: Conventional treatment | Biotronik GmbH & Co. KG |
| INSIGHT (R)XT. Indications for Diagnosis, Arrhythmia and Monitoring of Reveal XT (web link) | NA | Recruiting | Atrial Fibrillation Risk of Cardiac Arrhythmias | NA | NA | Medtronic - Vitatron |
| DISCOVERY: Diagnostic Data and Genetic Polymorphisms in ICD Patients. (web link) | Device | Recruiting | Death Sudden Cardiac Ventricular Fibrillation Tachycardia Atrial Fibrillation Sick Sinus Syndrome | Defibrillator, Dual Chamber ; Implantable (Phase IV) | Blood sampling | Medtronic Bakken Research Center |
| Odiparcil QT Definitive Study (web link) | Drug | Terminated | Atrial Fibrillation | Odiparcil (Phase I) | NA | GlaxoSmithKline |
| COMPARE-Adapta Study (web link) | Device | Active, not recruiting | Cardiac Pacemaker Artificial; Atrial Fibrillation | Medtronic Adapta Dual Chamber Pacemaker | NA | Medtronic Cardiac Rhythm Disease Management |
| Siemens 3-D C-Arm CT of the Heart Chambers (web link) | Other | Recruiting | Atrial Fibrillation | 3D C-arm CT scan | NA | The Cleveland Clinic Siemens Medical Solutions |
| Safety and Effectiveness of Left Atrial Appendage Occlusion (web link) | Device | Recruiting | Atrial Fibrillation | AtriCure LAA Exclusion System (Phase II) | NA | AtriCure, Inc. |
| Long-term Cardiac Monitoring After Cryptogenic Stroke (CMACS) (web link) | Device | Active, not recruiting | Stroke | Cardionet Mobile Cardiac Outpatient Telemetry (MCOT) ( Phase I) | NA | University of California, San Francisco |
| Optimal Sensing in Atrial Tachyarrhythmia's Study (web link) | Device | Recruiting | Sick Sinus Syndrome | Accent Pacemaker | Paroxysmal Atrial Fibrillation | St. Jude Medical |
| Impact of Left Atrial Appendage Exclusion on Short-Term Clinical Outcomes and Long-Term Stroke Incidence (web link) | Procedure | Recruiting | Atrial Fibrillation Thromboembolism Cerebrovascular Accident | Left Atrial Appendage Ligation | NA | London Health Sciences Centre Fondazione SanRaffaele del Monte Tabor |
| Change of Heart Rate Variability and Baroreflex Sensitivity After Ventral Cardiac Denervation : (web link) | Procedure | Unknown | Atrial Fibrillation | ventral cardiac denervation | NA | Far Eastern Memorial Hospital |
| Evaluation of Depolarization and Repolarisation Activity During Cardiac Arrhythmia Using a Novel Monophasic Action Potential Catheter (web link) | Device | Recruiting | Atrial Fibrillation; Ventricular Fibrillation; Tachycardia Ectopic Junctional | Cardiac chambers mapping with MAP 4 | NA | University Hospital, Bordeaux |
| Does Radioiodine Treatment Prevent Atrial Fibrillation and Bone Loss in Endogenous Subclinical Hyperthyroidism? (web link) | Procedure | Recruiting | Hyperthyroidism | treatment with 131I | NA | Radboud University |
| ALA and Prostate Cancer (web link) | Procedure | Unknown | Atrial Fibrillation Diet Therapy Prostate Cancer | ALA-rich diet (Phase II) | NA | University of Toronto |
| Long Term Open Follow-up With H376/95 vs. Warfarin (web link) | Drug | Terminated | Stroke Prevention in Patients With Atrial Fibrillation | Ximelagatran (Phase II) | NA | AstraZeneca |
| Effectiveness of Bridging Anticoagulation for Surgery (The BRIDGE Study) (web link) | Drug | Recruiting | Arterial Thromboembolic Events Atrial Fibrillation | Placebo (Phase III) | Dalteparin | National Heart, Lung, and Blood Institute (NHLBI) |
| Irrigated Ablation System Evaluation for AF (web link) | Device | Recruiting | Paroxysmal Atrial Fibrillation | SJM Irrigated Cardiac Ablation System; | FDA approved Open Irrigated RF Ablation System | St. Jude Medical |
| DISCOVERY: Diagnostic Data and Genetic Polymorphisms in ICD Patients. (web link) | Device | Recruiting | Death Sudden Cardiac Ventricular Fibrillation Tachycardia Atrial Fibrillation Sick Sinus Syndrome | Defibrillator, Dual Chamber ; Implantable (Phase IV) | Blood sampling | Medtronic Bakken Research Center |
| AVJ Ablation Followed by Resynchronization Therapy in Patients With CHF and AF (web link) | NA | Recruiting | Atrial Fibrillation Congestive Heart Failure | NA | NA | St. Jude Medical |
| COMPARE-Adapta Study (web link) | Device | Active, not recruiting | Cardiac Pacemaker Artificial Atrial Fibrillation | Medtronic Adapta Dual Chamber Pacemaker | NA | Medtronic Cardiac Rhythm Disease Management |
| Renin-Angiotensin-Aldosterone System (RAAS), Inflammation, and Post-Operative Atrial Fibrillation (web link) | Drug | Recruiting | Atrial Fibrillation | Placebo (Phase II|Phase III) | Ramipril | Vanderbilt University National Heart, Lung, and Blood Institute (NHLBI) |
| Safety and Effectiveness of Left Atrial Appendage Occlusion (web link) | Device | Recruiting | Atrial Fibrillation | AtriCure LAA Exclusion System (Phase II) | NA | AtriCure, Inc. |
| Use of Fish Oils to Prevent Atrial Mechanical Stunning and Atrial Remodeling Due to Atrial Arrhythmia (web link) | Drug | Recruiting | Atrial Fibrillation Atrial Flutter | Fish oil | NA | Melbourne Health |
| Long-term Cardiac Monitoring After Cryptogenic Stroke (CMACS) (web link) | Device | Active, not recruiting | Stroke | Cardionet Mobile Cardiac Outpatient Telemetry (MCOT) ( Phase I) | NA | University of California, San Francisco |
| Prolongation of the Interval Between Monitoring of Warfarin in Stable Patients (web link) | Drug | Recruiting | Atrial Fibrillation Heart Valve Diseases Venous Thrombosis | Prolongation of the interval between monitoring of warfarin (Phase II) | NA | Hamilton Health Sciences The Physicians' Services Incorporated Foundation |
| EUropean Pharmacogenetics of AntiCoagulant Therapy - Acenocoumarol (EU-PACT) (web link) | Other | Recruiting | Venous Thromboembolism Atrial Fibrillation | Genotype-guided dosing algorithm (Phase IV) | Non-genotype-guided dosing algorithm | Utrecht Institute for Pharmaceutical Sciences |
| A Retrospective Study of the Role of Thiazolidinediones to Reduce the Incidence of Atrial Arrhythmias (web link) | Procedure | Terminated | Atrial Fibrillation | TZD reducing the incidence of atrial arrhythmias (Phase II) | NA | Emory University |
| EUropean Pharmacogenetics of AntiCoagulant Therapy - Warfarin (EU-PACT) (web link) | Other | Not yet recruiting | Venous Thromboembolism Atrial Fibrillation | Genotype-guided dosing algorithm ( Phase IV) | Non-genotype-guided dosing algorithm | Utrecht Institute for Pharmaceutical Sciences |
| Reducing Episodes by Septal Pacing Efficacy Confirmation Trial (RESPECT) (web link) | Device | Recruiting | Atrial Fibrillation Tachycardia Supraventricular Arrhythmia Bradycardia | Implantable Pulse Generator | NA | Medtronic Cardiac Rhythm Disease Management |
| Safety and Efficacy of Lean Body Weight-based IV Heparin Dosing in Obese/Morbidly Obese Patients (web link) | Drug | Recruiting | Obesity Morbid Obesity Venous Thromboembolism Atrial Fibrillation Angina Chest Pain | Lean Body Weight-based heparin dose | NA | Nazareth Hospital |
| Atrial Tissue Banking: Atrial Tissue Obtained From Patients Undergoing Heart Surgery (web link) | NA | Recruiting | Atrial Fibrillation | NA | NA | University of Pittsburgh EP Research funds |
| Predictors of Anticoagulation Control on Warfarin Therapy (web link) | NA | Recruiting | Atrial Fibrillation Deep Vein Thrombosis Heart Valve Replacement | NA | NA | University of Pennsylvania |
| CONTAK RENEWAL 3 AVT (web link) | Device | Active, not recruiting | Heart Failure Atrial Fibrillation | CONTAK RENEWAL 3 AVT (Phase III) | NA | Boston Scientific Corporation |
| Telemetric Arrhythmia Diagnosis in Adults (TELEMARC1) (web link) | Device | Recruiting | Atrial Fibrillation Arrhythmia | "Prolonged telemetric Full Disclosure ECG recording. | NA | Institute of Cardiology, Warsaw, Poland |
| Electrophysiologically Guided PAcing Site Selection Study (web link) | Procedure | Not yet recruiting | Sinus Arrhythmia Atrial Fibrillation | IAS pacing (Phase IV) | RAA pacing | Medtronic - Vitatron Vitatron Medical Italia |
| INSIGHT (R)XT. Indications for Diagnosis, Arrhythmia and Monitoring of Reveal XT (web link) | NA | Recruiting | Atrial Fibrillation Risk of Cardiac Arrhythmias | NA | NA | Medtronic BRC |
| A Clinical Study of the Arctic Front Cryoablation Balloon for the Treatment of Paroxysmal Atrial Fibrillation (web link) | Device | Recruiting | Paroxysmal Atrial Fibrillation | Arctic Front Cryoablation Catheter (Phase III) | Drug: Flecainide or Sotalol or Propafenone | CryoCath Technologies Inc. |
| IDE Study for the Approval of CLS and CRT Pacing Therapies for the Treatment of AF With Ablate and Pace (web link) | Device | Active, not recruiting | Atrial Fibrillation Congestive Heart Failure | Protos DR/CLS and Stratos LV CRT pacemakers | NA | Biotronik, Inc. |
| WOEST ( What is the Optimal antiplatElet & Anticoagulant Therapy in Patients With Oral Anticoagulation and Coronary StenTing) (web link) | Device | Recruiting | Anticoagulants Platelet Aggregation Inhibitors Stents Atrial Fibrillation | PCI (percutaneous coronary intervention) ( Phase IV) | NA | R&D Cardiologie |
| Treatment of Subclinical Hyperthyroidism (web link) | NA | Recruiting | Subclinical Hyperthyroidism Atrial Fibrillation | NA | NA | University Hospital, Strasbourg, France |
| Study of Normal Conditions of Use, Dosing, and Safety of Intravenous (IV) Administration of Vernakalant (MK-6621-049) (web link) | Drug | Not yet recruiting | Atrial Fibrillation | Vernakalant | NA | Merck |
| Cryoenergy Or Radiofrequency for Pulmonary Vein Isolation (COR) (web link) | Device | Unknown | Atrial Fibrillation | Pulmonary vein cryoablation (Phase IV) | Pulmonary vein radiofrequency ablation | Hospital San Carlos, Madrid |
| Randomized Evaluation of Long Term Anticoagulant Therapy (RE-LY) With Dabigatran Etexilate (web link) | Drug | Active, not recruiting | Atrial Fibrillation Cerebrovascular Accident | Dabigatran etexilate (Phase III) | Warfarin | Boehringer Ingelheim Pharmaceuticals |
| Siemens 3-D C-Arm CT of the Heart Chambers (DynaC-Arm) (web link) | Other | Unknown | Atrial Fibrillation | 3D C-arm CT scan | NA | The Cleveland Clinic |
| Prophylactic Pulmonary Vein Isolation Study (web link) | Procedure | Recruiting | Atrial Fibrillation | Pulmonary Vein Isolation | NA | Mayo Clinic AtriCure, Inc. |
| Strategy of Early Detection and Active Management of Supraventricular Arrhythmia With Telecardiology (SETAM) (web link) | Other | Recruiting | Atrial Fibrillation Atrial Flutter Atrial Tachycardia | Telecardiology | NA | Biotronik France |
| Comparison of ATI-5923, a Novel Vitamin K Antagonist, With Warfarin in Patients Requiring Chronic Anticoagulation (web link) | Drug | Recruiting | Atrial Fibrillation Atrial Flutter Venous Thromboembolic Disease Myocardial Infarction Cardiomyopathy | ATI-5923 (Phase II|Phase III) | Coumadin (warfarin) | ARYx Therapeutics |
| Observatory on Elderly Patients "Les S.AGES" (web link) | Procedure | Recruiting | Diabetes Mellitus Type 2 Chronic Pain Atrial Fibrillation | Left Atrial Appendage Ligation | NA | Sanofi-Aventis |
| A Case Control Study to Investigate the Possible Association Between Atrial Fibrillation and Endothelium Dysfunction by Using Flow-Mediated Vasodilation Method (web link) | NA | Recruiting | Atrial Fibrillation Endothelial Function | NA | NA | National Taiwan University Hospital |
| Atrial Substrate Modification With Aggressive Blood Pressure Lowering to Prevent AF (SMAC AF) (web link) | Other | Recruiting | Atrial Fibrillation Catheter Ablation | Aggressive BP lowering (Phase IV) | NA | Capital District Health Authority, Canada |
| Genetic Study of Atrial Fibrillation: Focusing on Renin-Angiotensin System and C-Reactive Protein Genes (web link) | NA | Recruiting | Atrial Fibrillation | NA | NA | National Taiwan University Hospital |
| Transesophageal Echocardiography to Identify pAtients With Low Risk of Stroke in Atrial Fibrillation - TIARA Pilot Study (web link) | Procedure | Unknown | Atrial Fibrillation Stroke | Transoesophageal echocardiography | NA | The Interuniversity Cardiology Institute of the Netherlands |
| Study to Characterize Atrial Fibrillation in CHF Patients Indicated for CRT (web link) | Device | Active, not recruiting | Congestive Heart Failure Atrial Fibrillation | Vitatron biventricular pacemaker (Phase IV) | NA | Medtronic - Vitatron |
| Genomics and Postoperative Atrial Fibrillation (web link) | http://clinicaltrials.gov/ct2/show/NCT00280163 | Unknown | Postoperative Atrial Fibrillation Genomics | Postoperative Atrial Fibrillation, Genomics | NA | University of Pittsburgh |
| Study of Ablation Versus antiaRrhythmic Drugs in Persistent Atrial Fibrillation (SARA) (web link) | Drug | Recruiting | Atrial Fibrillation | Atrial fibrillation ablation (Phase IV) | Antiarrhythmic drug | Hospital Clinic of Barcelona |
| Improving the Quality of Care for Atrial Fibrillation by Promoting Patient-Centered Decision Making (AFIB) (web link) | NA | NA | Atrial Fibrillation | Decision Aid for Atrial Fibrillation (Phase I) | Usual Care | VA Connecticut Healthcare System |
| Impact of Dabigatran and Phenprocoumon on Clopidogrel Mediated ADP Induced Platelet Aggregation in Patients With Atrial Fibrillation (Dabi-ADP-2) (web link) | Drug | Recruiting | Coronary Heart Disease Atrial Fibrillation Acute Coronary Syndrome Atherosclerosis | Dabigatran (Phase IV) | Phenprocoumon | Deutsches Herzzentrum Muenchen |
| Navi-Star Thermo-Cool Catheter For Ablation of Atrial Fibrillation (web link) | Device | Active, not recruiting | Atrial Fibrillation | Catheter Ablation (NAVI-STAR THERMO-COOL catheter) | NA | University of Oklahoma |
| FLAT Study: First Line Ablation Therapy for Treatment of Paroxysmal Atrial Fibrillation (web link) | Device | Terminated | Atrial Fibrillation | RF ablation (Phase IV) | Drug: anti-arrhythmic drug therapy | Biosense Webster EMEA |
| Impact of Left Atrial Appendage Exclusion on Short-Term Clinical Outcomes and Long-Term Stroke Incidence (web link) | NA | Recruiting | Atrial Fibrillation Thromboembolism Cerebrovascular Accident | NA | NA | London Health Sciences Centre |
| Explorative Study of AZD1305 in Atrial Fibrillation Patients (web link) | Drug | Recruiting | Atrial Fibrillation | AZD1305 (Phase II) | Placebo | AstraZeneca |
| Effect of Remote Ischemic Preconditioning on Cardiac Function After Cardiac Surgery (web link) | Procedure | Unknown | Atrial Fibrillation Ventricular Arrythmias Myocardial Injury Cardiac Function | Remote Ischemic Preconditioning ( Phase I) | NA | University of Schleswig-Holstein |
| Comparison of Two Potassium Targets Within the Normal Range in Intensive Care Patients (GRIP-COMPASS) (web link) | Drug | Recruiting | Thoracic Surgery Cardiac Surgery Critically Ill | Potassium Chloride (Phase IV) | NA | University Medical Centre Groningen |
| Cryptogenic Stroke Study (web link) | Device | Unknown | Cryptogenic Stroke | Sleuth AT Implantable ECG Monitoring System | NA | Transoma Medical |
| Amiodarone Compared to Dronedarone , Post Cardioversion Maintenance of Sinus Rhythm (ACDC) (web link) | Drug | Not yet recruiting | Atrial Fibrillation | amiodarone | Dronedarone | Eastbourne General Hospital |
| Statin and PAF in Patients With Pacemaker (web link) | Drug | Recruiting | Paroxysmal Atrial Fibrillation | Statin | NA | National Taiwan University Hospital |
| REVOLUTION (WFCC-133) (web link) | Device | Recruiting | Paroxysmal Atrial Fibrillation | Circular Mapping and Ablation catheter (Phase IV) | Crescent Mapping and Ablation catheter | Biosense Webster, Inc |
| Safety and Efficacy of CryoCor™ Cryoablation for PAF (web link) | Device | Recruiting | Atrial Fibrillation | Cardiac cryoablation (Phase III) | NA | CryoCor |
| Telemetric Arrhythmia and Syncope Diagnosis - Evaluation of Arrhythmia Treatment Efficacy (TELEMARC 4) (web link) | Device | Recruiting | Atrial Fibrillation
Arrhythmias Cardiac | " Prolonged telemetric Full Disclosure ECG recording. | NA | Institute of Cardiology, Warsaw, Poland |
| Biochemical Marker to Predict the Recurrence of Atrial Fibrillation After Surgical Maze Procedure (web link) | NA | Recruiting | Atrial Fibrillation | NA | NA | Samsung Medical Center |
| EvaluAtion of Predictive Value of Multisite Intracardiac EchoCardiography During Imaging of Structure and funCTION of Left Atrial Appendage in Comparison to Transesophageal Echocardiography (ActionICE) (web link) | Device | Recruiting | Atrial Fibrillation | Intra-Cardiac Echocardiography guided atrial fibrillation ablation (Phase IV) | NA | Medical Centre of Postgraduate Education, Poland |
| Inflammatory and Fibrotic Markers and Atrial Fibrillation (web link) | NA | Recruiting | Atrial Fibrillation | NA | NA | National Taiwan University Hospital |
| Peri-operative Oral Triiodothyronine Replacement Therapy to Decrease the Risk of Transient Atrial Fibrillation After Off-pump Coronary Artery Bypass Surgery (web link) | Drug | Recruiting | Coronary Artery Occlusive Disease | liothyronine sodium | NA | Yonsei University |
| Ventricular Pacing Site Selection (V-PASS) (web link) | Procedure | Not yet recruiting | Atrioventricular Block | Leads to be implanted according randomization on specified sites. Vitatron pacemakers to be implanted: T60 DR, T70 DR, T20 SR, C60 DR (Phase IV) | NA | Medtronic - Vitatron Vitatron GmbH |
| Dronedarone Pattern of Use in Patients Scheduled for Elective Cardioversion (ELECTRA) (web link) | Drug | Active, not recruiting | Atrial Fibrillation | DRONEDARONE (Phase IV) | PLACEBO DRONEDARONE | Sanofi-Aventis |
| Radiofrequency Ablation (RFA) Versus Antiarrhythmic Drug Treatment in Paroxysmal Atrial Fibrillation (web link) | Procedure | Recruiting | Atrial Fibrillation | Radiofrequency ablation (Phase III) | NA | Danish Heart Foundation |
| Intra-Cardiac Echocardiography Guided Cardioversion to Help Interventional Procedures (ICE-CHIP) Study (web link) | Device | Recruiting | Atrial Fibrillation | Intra-Cardiac Echocardiography guided Cardioversion (Phase I|Phase II) | NA | EP MedSystems |
| AMPLATZER Cardiac Plug Clinical Trial (web link) | Device | Active, not recruiting | Atrial Fibrillation | AMPLATZER Cardiac Plug (Phase I) | NA | AGA Medical Corporation |
| Reveal® XT Performance Trial (XPECT) (web link) | Other | Recruiting | Atrial Fibrillation Risk of Cardiac Arrhythmias | 46 hrs Holter ECG recording (Phase IV) | NA | Medtronic - Vitatron |
| Does Atorvastatin Prevent Post Operative Atrial Fibrillation After Pulmonary Resection: A Randomized Clinical Study (web link) | Drug | Unknown | Arrhythmia | Atorvastatin | NA | University of Alabama at Birmingham |
| Comparative Study of Flecainide CR and Placebo in the Early Treatment of Atrial Fibrillation. (web link) | Drug | Terminated | Atrial Fibrillation | Flecainide (Phase IV) | NA | MEDA Pharma GmbH & Co. KG 3M |
| Efficacy Study for Surgery After Previous Failed Catheter Ablation (SAVED) (web link) | Procedure | Active, not recruiting | Atrial Fibrillation Ablation | Totally Thoracoscopic Maze | NA | Cardiopulmonary Research Science and Technology Institute |
| Ventricular Pacing Site Selection (V-PASS) (web link) | Procedure | Unknown | Atrioventricular Block | "Leads to be implanted according randomization on specified sites. Vitatron pacemakers to be implanted: T60 DR, T70 DR, T20 SR, C60 DR (Phase IV) | NA | Medtronic BRC |
| AtriCure Bipolar Radiofrequency Ablation of Persistent Atrial Fibrillation (web link) | Device | Withdrawn | Atrial Fibrillation | AtriCure Bipolar System (Phase III) | NA | AtriCure, Inc. |
| Atrial Fibrillation Incidence, Risk Factors and Genetics (web link) | NA | Active, not recruiting | Atrial Fibrillation Cardiovascular Diseases Heart Diseases Hypertension Cerebrovascular Accident Arrhythmia | NA | NA | National Heart, Lung, and Blood Institute (NHLBI) |
| Implantable Loop Recorders in Post-atrial Fibrillation (AF) Ablation: RPAF-A (web link) | NA | Recruiting | Atrial Fibrillation | NA | NA | The Cleveland Clinic |
| RAte Control Efficacy in Permanent Atrial Fibrillation (web link) | Procedure | Active, not recruiting | Persistant Atrial Fibrillation | Strict versus lenient rate control | NA | University Medical Centre Groningen Netherlands Heart Foundation |
| Cytochrome P450 2D6 (CYP 450 2D6) Genotype and Flecainide Efficacy (web link) | NA | Unknown | Atrial Fibrillation | NA | NA | Assaf-Harofeh Medical Center |
| Study of K201 Injection on Restoration of Sinus Rhythm in Subjects Who Are in Atrial Fibrillation (web link) | Drug | Recruiting | Atrial Fibrillation | K201 Injection (Phase II) | NA | Sequel Pharmaceuticals, Inc |
| Inflammatory and Fibrotic Markers and Atrial Fibrillation (web link) | NA | Unknown | Atrial Fibrillation | NA | NA | National Taiwan University Hospital |
| Transesophageal Echocardiography to Identify pAtients With Low Risk of Stroke in Atrial Fibrillation - TIARA Pilot Study (web link) | Procedure | Recruiting | Atrial Fibrillation Stroke | Transoesophageal echocardiography | NA | The Interuniversity Cardiology Institute of the Netherlands |
| Corticosteroid Pulse After Ablation (SAAB) (web link) | Drug | Active, not recruiting | Atrial Fibrillation | Solumedrol (Phase IV) | Placebo | Minneapolis Heart Institute Foundation |
| RELY-ABLE Long Term Multi-center Extension of Dabigatran Treatment in Patients With Atrial Fibrillation Who Completed RE-LY Trial (web link) | Drug | Active, not recruiting | Atrial Fibrillation | dabigatran dose 2 (Phase III) | dabigatran dose 1 | Boehringer Ingelheim Pharmaceuticals |
| Study of Amiodarone Given Before Lung Surgery to Prevent Atrial Fibrillation After Lung Resection (web link) | Drug | Recruiting | Atrial Fibrillation Lung Cancer | Amiodarone (Phase III) | Amiodarone | Beth Israel Deaconess Medical Center |
| Study of the Effect of Cardioversion on Cardiac Volume in Patients With Persistent Atrial Fibrillation (web link) | Procedure | Terminated | Atrial Fibrillation | cardioversion | NA | Hvidovre University Hospital The Foundation of 17.12.1981 The A.P. Moeller Foundation for the Advancement of Medical Science Danish Hospital Foundation for Medical Research, Region of Copenhagen Danish Heart Foundation Copenhagen Hospital Corporation |
| The Use of Dual Chamber ICD With Special Programmed Features to Lower the Risk of Inappropriate Shock (RAPTURE) (web link) | Drug | Active, not recruiting | Ventricular Tachycardia Ventricular Fibrillation Atrial Fibrillation Supraventricular Tachycardia | ICD (Phase IV) | NA | Mayo Clinic |
| Genomics and Postoperative Atrial Fibrillation (web link) | NA | Recruiting | Postoperative Atrial Fibrillation Genomics | NA | NA | University of Pittsburgh |
| Linear Ablation Versus Focal Ablation of Complex Fractionated Atrial Electrograms in Persistent Atrial Fibrillation (web link) | Procedure | Recruiting | Persistent Atrial Fibrillation | radiofrequency catheter ablation | NA | Korea University Anam Hospital |
| Esophagus Imaging for Radiofrequency Ablation of Atrial Fibrillation (web link) | Procedure | Recruiting | Atrial Fibrillation | placing gastric tube | NA | Kantonsspital Luzern |
| CONcomitant eValuation of Epicor Left atRial Therapy for AF (CONVERT-AF) (web link) | Drug | Recruiting | Atrial Fibrillation | Epicor LP Cardiac Ablation System | Surgical ablation of permanent AF | St. Jude Medical |
| N-3 Fatty Acids for the Prevention of Atrial Fibrillation in Patients With Acute Heart Failure (web link) | Drug | Not yet recruiting | Acute Heart Failure | Epadel, Eicosapentaenoic acid (Phase IV) | NA | Osaka General Medical Center |
| Secondary Prevention of Atrial Fibrillation (Impact of Renin-Angiotensin-Aldosterone System Inhibition) (web link) | Drug | Enrolling by invitation | Atrial Fibrillation | start cozaar (Phase IV) | continue cozaar | University of Pittsburgh |
| Substrate and Trigger Ablation for Reduction of Atrial Fibrillation Trial -Star AF II Study (web link) | Device | Recruiting | Atrial Fibrillation | PVI + Lines ablation | PVI | St. Jude Medical |
| Arrhythmia Restart Prevention and RatE STabilization in Atrial Fibrillation (web link) | Device | Recruiting | Sick Sinus Syndrome Brady-Tachy Syndrome | Pacemaker Vitatron Selection 9000 (Phase IV) | Pacemaker Vitatron T70 | Vitatron France |
| Ablation of Perimitral Flutter Following Catheter Ablation of Atrial Fibrillation: Impact on Outcomes (PROPOSE) (web link) | Procedure | Recruiting | Atrial Fibrillation Perimitral Flutter | catheter ablation (Phase III) | NA | Texas Cardiac Arrhythmia Research Foundation |
| A Randomized Study to Demonstrate the Safety and Feasibility of Plexisyl-AF in Patients Undergoing CABG (web link) | Device | Recruiting | Atrial Fibrillation | Plexisyl-AF | Other: No Treatment | Symphony Medical, Inc. |
| Certain People With A Fib May Have Changes on Ecg When Given Procainamide That May be Related to a Genetic Difference (web link) | Drug | Recruiting | Atrial Fibrillation | Procainamide | NA | Vanderbilt University |
| Primary Anatomical Versus Primary Electrophysiological Approach in Circumferential Pulmonary Vein Ablation (web link) | Procedure | Not yet recruiting | Paroxysmal Atrial Fibrillation | primary electrophysiological approach | primary anatomical approach | University Hospital, Bonn |
| Impact of Dabigatran and Phenprocoumon on ADP Induced Platelet Aggregation in Patients With Atrial Fibrillation (Dabi-ADP-1) (web link) | Drug | Recruiting | Atrial Fibrillation | Dabigatran (Phase IV) | Phenprocoumon | Deutsches Herzzentrum Muenchen |
| Bi-Ventricular Pacing in Patients With Atrial Fibrillation and Heart Failure (BIFF-Study) (web link) | Device | Active, not recruiting | Heart Failure | InSync III (Phase II) | NA | Umeå University |
| Selective AV Nodal Vagal Stimulation For Reduction of the Ventricular Rate During Atrial Fibrillation (web link) | NA | Withdrawn | Atrial Fibrillation | NA | NA | The Cleveland Clinic |
| Ventricular Rate Regularization for Improved Quality of Life in Patients With CHF and AF (web link) | NA | Recruiting | Congestive Heart Failure Atrial Fibrillation | NA | NA | University of California, Davis Guidant Corporation |
| Role of Coumadin in Preventing Thromboembolism in Atrial Fibrillation (AF) Patients Undergoing Catheter Ablation (COMPARE) (web link) | Drug | Recruiting | Thromboembolism | Coumadin (Phase III) | NA | Texas Cardiac Arrhythmia Research Foundation |
| AV Node Ablation and Pacemaker Therapy Compared to Drug Therapy for Atrial Fibrillation - Pilot Study (web link) | Drug | Recruiting | Atrial Fibrillation Heart Failure | FDA approved rate and rhythm control drugs (Phase III) | Device: AV Node ablation and device implant | Mayo Clinic Medtronic |
| A Retrospective Analysis of the Use of ACE-Inhibitors and Angiotensin Receptor Blockers (web link) | Procedure | Active, not recruiting | Atrial Fibrillation Atrial Flutter | ACE-Inhibitors and Angiotensin Receptor Blockers (Phase II) | NA | Emory University |
| Oral Steroids Before Pulmonary Vein Isolation to Improve Outcomes (web link) | Drug | Unknown | Atrial Fibrillation | Ablation plus prednisone | Ablation plus placebo | University of Kansas |
| Irbesartan and Adhesion Molecules in AF (web link) | Drug | Not yet recruiting | Persistent Atrial Fibrillation | irbesartan (Phase IV) | placebo | University of Magdeburg Sanofi-Aventis |
| TReatment of Atrial Fibrillation With Dual dEfibrillator in Heart Failure Patients (TRADE HF) (web link) | Device | Active, not recruiting | Heart Failure Congestive | Dual (atrial and ventricular) implantable defibrillator (Phase IV) | NA | Guidant Corporation |
| Prospective Clinical Study of the Guidant Microwave Ablation System for the Treatment of PAF in the MIS Procedure (web link) | Device | Suspended | Atrial Fibrillation | Microwave Ablation System | NA | Maquet Cardiovascular |
| Bi-Ventricular Pacing in Patients With Atrial Fibrillation and Heart Failure (BIFF-Study) (web link) | Device | Unknown | Heart Failure | InSync III (Phase II) | NA | Umeå University |
| A Retrospective Analysis of the Predictive Potential of Pre-Operative (web link) | Procedure | Terminated | Coronary Artery Bypass | Atrial Fibrillation (Phase II) | NA | Emory University |
| Primary Anatomical Versus Primary Electrophysiological Approach in Circumferential Pulmonary Vein Ablation (CPVA-PAF) (web link) | Procedure | Unknown | Paroxysmal Atrial Fibrillation | primary electrophysiological approach | primary anatomical approach | University Hospital, Bonn |
| Flecainide-Short Long Study (Flec-SL) (web link) | Drug | Recruiting | Atrial Fibrillation | Flecainid | NA | German Atrial Fibrillation Network German Federal Ministry of Education and Research 3M German Research Foundation (DFG, formal appplication pending) |
| N-3 Fatty Acids for the Prevention of Atrial Fibrillation in Patients With Acute Heart Failure (web link) | Ablation plus placebo | Unknown | Acute Heart Failure Acute Myocardial Infarction | Epadel (Phase IV) | Eicosapentaenoic acid | Osaka General Medical Center |
| Irbesartan for the Prevention of Atrial Arrhythmias and Cardiac Electrical Remodeling in Patients With Hypertension and Permanent Pacemakers (web link) | Drug | Not yet recruiting | Atrial Fibrillation Hypertension | Irbesartan (Phase III) | NA | Connolly, Stuart, M.D. Sanofi-Aventis Bristol-Myers Squibb |
| AV-node Stimulation Download Study (AVNS) (web link) | Device | Enrolling by invitation | Atrial Fibrillation | Consulta downloaded with AVNS (AV-node stimulation) algorithm to provide high frequency bursting. | NA | Medtronic BRC |
| RATAF -RATe Control in Atrial Fibrillation (web link) | Drug | Recruiting | Atrial Fibrillation | Metoprolol, Verapamil, Diltiazem, Carvedilol. (Phase III) | NA | Asker & Baerum Hospital |
| Effect of Structural Remodeling on Scar Formation as Assessed by DE-MRI of the Left Atrium (RADAR)University of Utah (web link) | NA | Enrolling by invitation | Atrial Fibrillation | NA | NA | University of Utah |
| Safety and Effectiveness of Left Atrial Appendage Occlusion (web link) | Device | Recruiting | Atrial Fibrillation | AtriCure LAA Occlusion System (Phase II) | NA | AtriCure, Inc. |
| Ventricular Rate Regularization for Improved Quality of Life in Patients With CHF and AF (VRR) (web link) | NA | Unknown | Congestive Heart Failure Atrial Fibrillation | NA | NA | University of California, Davis |
| Follow-up Treatment of Patients With Atrial Fibrillation Who Have Been Previously Treated With BIBR 1048 (web link) | Drug | Active, not recruiting | Atrial Fibrillation Cerebrovascular Accident | Dabigatran etexilate (Phase II) | NA | Boehringer Ingelheim Pharmaceuticals |
| Role of Coumadin in Preventing Thromboembolism in Atrial Fibrillation (AF) Patients Undergoing Catheter Ablation (COMPARE) (web link) | Drug | Recruiting | Thromboembolism | Coumadin (Phase III) | NA | Texas Cardiac Arrhythmia Research Foundation |
| Oral Steroids Before Pulmonary Vein Isolation to Improve Outcomes (web link) | Drug | Unknown | Atrial Fibrillation | Ablation plus prednisone | Ablation plus placebo | University of Kansas |
| The Use of Statins Following a Left Atrial Catheter Ablation Procedure to Prevent Atrial Fibrillation (web link) | Drug | Recruiting | Atrial Fibrillation Arrhythmia Inflammation Endothelial Dysfunction | Atorvistatin (Phase IV) | Placebo | Mayo Clinic Pfizer |
| Studies of the Prevention of Atrial Fibrillation by ALA (web link) | Procedure | Active, not recruiting | Atrial Fibrillation Diet Therapy | ALA rich diet (Phase II) | NA | University of Toronto University Hospital, Bordeaux Institut National de la Santé Et de la Recherche Médicale, France |
| TReatment of Atrial Fibrillation With Dual dEfibrillator in Heart Failure Patients (TRADE HF) (web link) | Device | Active, not recruiting | Heart Failure Congestive | " Dual (atrial and ventricular) implantable defibrillator (Phase IV) | NA | Guidant Corporation |
| Bi-Ventricular Pacing in Patients With Atrial Fibrillation and Heart Failure (BIFF-Study) (web link) | Device | Unknown | Heart Failure | InSync III (Phase II) | NA | Umeå University |
| A Study Comparing Once Daily Oral Rivaroxaban With Adjusted-Dose Oral Warfarin for the Prevention of Stroke in Subjects With Non-Valvular Atrial Fibrillation (web link) | Drug | Recruiting | Atrial Fibrillation Stroke | Rivaroxaban (BAY59-7939) (Phase III) | Warfarin | Bayer Johnson & Johnson Pharmaceutical Research & Development, L.L.C. |
| Primary Anatomical Versus Primary Electrophysiological Approach in Circumferential Pulmonary Vein Ablation (CPVA-PAF) (web link) | Procedure | Unknown | Paroxysmal Atrial Fibrillation | primary electrophysiological approach | primary anatomical approach | University Hospital, Bonn |
| N-3 Fatty Acids for the Prevention of Atrial Fibrillation in Patients With Acute Heart Failure (web link) | Drug | Unknown | Acute Heart Failure Acute Myocardial Infarction | Epadel (Phase IV) | Eicosapentaenoic acid | Osaka General Medical Center |
| The Effect of Losartan on Atrial Fibrillation (AF) Burden and Pacemaker Dependence in Patients With Sick Sinus Syndrome (web link) | Drug | Active, not recruiting | Atrial Fibrillation | Losartan | Placebo | Chung Shan Medical University |
| AV-node Stimulation Download Study (AVNS) (web link) | Device | Enrolling by invitation | Atrial Fibrillation | Consulta downloaded with AVNS (AV-node stimulation) algorithm to provide high frequency bursting. | NA | Medtronic BRC |
| Effect of Structural Remodeling on Scar Formation as Assessed by DE-MRI of the Left Atrium (RADAR)University of Utah (web link) | NA | Enrolling by invitation | Atrial Fibrillation | NA | NA | University of Utah |
| Evaluation of Weekly Subcutaneous Biotinylated Idraparinux Versus Oral Adjusted-Dose Warfarin to Prevent Stroke and Systemic Thromboembolic Events in Patients With Atrial Fibrillation (web link) | Drug | Recruiting | Atrial Fibrillation | SSR126517E biotinylated idraparinux (Phase III) | warfarin | Sanofi-Aventis |
| Ventricular Rate Regularization for Improved Quality of Life in Patients With CHF and AF (VRR) (web link) | NA | Unknown | Congestive Heart Failure Atrial Fibrillation | NA | NA | University of California, Davis |
| A Retrospective Analysis of the Use of ACE-Inhibitors and Angiotensin Receptor Blockers (web link) | Procedure | Unknown | Atrial Fibrillation Atrial Flutter | ACE-Inhibitors and Angiotensin Receptor Blockers (Phase II) | NA | Emory University |
| Mascot Study: Management of Atrial Fibrillation (AF) Suppression in AF-Heart Failure (HF) COmorbidity Therapy (web link) | Device | Active, not recruiting | Heart Failure Atrial Fibrillation Ventricular Dysfunction | Atrial Overdrive Pacing | NA | St. Jude Medical |
| Arrhythmia Restart Prevention and RatE STabilization in Atrial Fibrillation (web link) | Device | Unknown | Sick Sinus Syndrome Brady-Tachy Syndrome | Pacemaker Vitatron Selection 9000 (Phase IV) | Pacemaker Vitatron T70 | Vitatron France |
| Heart Rate Regularization in Patients With Permanent Atrial Fibrillation Post Marketing Study (web link) | Device | Not yet recruiting | Atrial Fibrillation | Function Ventricular Rate Stabilization (Phase IV) | NA | Medtronic - Vitatron Vitatron Medical Italia |
| Irbesartan and Adhesion Molecules in AF (CREATIVE-AF) (web link) | Drug | Unknown | Persistent Atrial Fibrillation | irbesartan | placebo | |
| Treatment of Atrial Fibrillation by Minimal Invasive Surgery (web link) | Procedure | Active, not recruiting | Atrial Fibrillation | ablation of pulmonary veins by video assisted thoracic surgery (Phase II) | NA | University Medical Centre Groningen |
| MODULA Modul 7 VRR: Correlation Between Ventricular Rate Regulation (VRR) and the Percentage of Biventricular Pacing in Cardiac Resynchronization Therapy (CRT) Patients With Atrial Fibrillation (web link) | Device | Terminated | Atrial Fibrillation | CRT devices with ventricular rate regulation [VRR] (CE labeled) (Phase IV) | NA | Guidant Corporation |
| Effects of Fish Oil on Post Ablation Arrhythmias (web link) | Drug | Unknown | Atrial Fibrillation | LOVAZA Omega 3-acid ethyl esters (Phase IV) | LOVAZA | University of Michigan, Section of Electrophysiology (Arrhythmia Research) |
| SAFE Study - Septal Pacing for Atrial Fibrillation Suppression Evaluation (web link) | Device | Recruiting | Atrial Fibrillation | Pacemaker implantation | NA | St. Jude Medical |
| Irbesartan for the Prevention of Atrial Arrhythmias and Cardiac Electrical Remodeling in Patients With Hypertension and Permanent Pacemakers (web link) | Drug | Unknown | Atrial Fibrillation; Stroke | Irbesartan (Phase III) | NA | AtriCure, Inc. |
| Left Atrial Appendage Occlusion Study II (LAAOSII) (web link) | Procedure | Recruiting | Atrial Fibrillation; Stroke | Surgical occlusion of the left atrial appendage (Phase III) | Best medical practice | Population Health Research Institute |
| QT Variability Pre and Post Cardioversion (DCCV) (web link) | NA | Recruiting | Atrial Fibrillation | NA | NA | Vanderbilt University |
| Apixaban for the Prevention of Stroke in Subjects With Atrial Fibrillation (web link) | Drug | Recruiting | Atrial Fibrillation Atrial Flutter | warfarin (Phase III) | apixaban | Bristol-Myers Squibb |
| Occult Paroxysmal Atrial Fibrillation in Patients With Non-cardioembolic Ischemic Stroke of Determined Mechanism (web link) | NA | Recruiting | Atrial Fibrillation; Stroke | NA | NA | Northwestern University |
| Evaluating the Effectiveness of Fish Oil Supplements at Reducing the Recurrence of Atrial Fibrillation (web link) | Drug | Recruiting | Atrial Fibrillation | Fish Oil (Phase IV) | Placebo | National Heart, Lung, and Blood Institute (NHLBI) eCardio Reliant Pharmaceuticals |
| ASA Plavix Feasibility Study With WATCHMAN Left Atrial Appendage Closure Technology (ASAP) (web link) | Device | Recruiting | Atrial Fibrillation | WATCHMAN | NA | Atritech |
| Flecainide-Short Long Study (Flec-SL) (web link) | Drug | Unknown | Atrial Fibrillation | Flecainid | NA | German Atrial Fibrillation Network |
| A Prospective Randomized Study Comparing Radiofrequency Energy With Cryoenergy (CRYO-RF) (web link) | Procedure | Unknown | Atrial Fibrillation Ablation | PVI using an open irrigated tip catheter (Phase IV) | PVI using a closed irrigated tip catheter | Herz-Zentrums Bad Krozingen |
| Changes in Myocardial Perfusion During Chronic Multi Site Biventricular Versus Right Ventricular Apex Pacing in Patients With Normal Left Ventricular Function Undergoing His Bundle Ablation for Drug-Refractory Atrial Fibrillation (web link) | Device | Not yet recruiting | Atrial Fibrillation | HIS buldle ablation | NA | R&D Cardiologie |
| ABLATE AF Registry Trial (web link) | Device | Recruiting | Atrial Fibrillation | AtriCure Bipolar System (Phase III) | NA | AtriCure, Inc |
| RATAF -RATe Control in Atrial Fibrillation (web link) | Drug | Active, not recruiting | Atrial Fibrillation | Metoprolol (Phase III) | Verapamil | Asker & Baerum Hospital |
| Circumferential vs Ganglionic Plexi Ablation for Atrial Fibrillation (AF) (web link) | Procedure | Not yet recruiting | Atrial Fibrillation | Circumferential ablation for PV isolation | Circumferential ablation and GP ablation | Cardiovascular Research Society, Greece |
| Anticoagulation in Stent Intervention (MUSICA-2) (web link) | NA | Recruiting | Atrial Fibrillation; Stroke | NA | NA | |
| CACAF2 Study: Catheter Ablation for Cure of Atrial Fibrillation (web link) | Device | Active, not recruiting | Atrial Fibrillation | RF ablation (Phase IV) | Drug: Drug therapy | Biosense Webster EMEA |
| Effects of Dronedarone on Cardiac Geometry and Function in Patients With Atrial Fibrillation and Left Atrial Enlargement (ODYSSEUS) (web link) | Recruiting | Atrial Fibrillation | DRONEDARONE (SR33589) (Phase IV) | placebo | Sanofi-Aventis | |
| Safety Monitoring of Patients Having Pulmonary Vein Ablation (web link) | NA | Recruiting | Atrial Fibrillation | NA | NA | The Cleveland Clinic |
| Warfarin - How Good Are we at Maintaining Target Range ? Atrial Fibrillation (web link) | Active, not recruiting | NA | NA | University of Dundee | ||
| LEAF - Low Energy In Atrial Fibrillation (web link) | Device | Terminated | Atrial Fibrillation Atrial Tachyarrhythmia | Medtronic AT500 (Phase IV) | NA | Medtronic Bakken Research Center Medtronic |
| Permanent Atrial fibriLLAtion Outcome Study Using Dronedarone on Top of Standard Therapy (PALLAS) (web link) | Drug | Active, not recruiting | Atrial Fibrillation | Dronedarone (SR33589) (Phase III) | placebo | Sanofi-Aventis |
| Mode Evaluation in Sick Sinus Syndrome Trial (MODEST) (web link) | Device | Recruiting | Sick Sinus Syndrome | Vitatron T70 DR (Phase IV) | NA | Medtronic - Vitatron Vitatron GmbH |
| Heart Rate Regularization in Patients With Permanent Atrial Fibrillation Post Marketing Study (web link) | Device | Unknown | Atrial Fibrillation | Function Ventricular Rate Stabilization (Phase IV) | NA | Medtronic BRC |
| APAF: Assessment of Cardiac Resynchronization Therapy in Patients With Permanent Atrial Fibrillation (web link) | Other | Recruiting | Congestive Heart Failure Atrial Fibrillation | Optimized echo-guided CRT pacing (Phase III) | normal RV pacing | Arcispedale Santa Maria Nuova Medtronic |
| Pharmacokinetics and Optimal Timing of Dronedarone Initiation Following Long-term Amiodarone in Patients With Paroxysmal or Persistent Atrial Fibrillation (ARTEMIS AF LT) (web link) | Drug | Recruiting | Atrial Fibrillation | DRONEDARONE (Phase IV) | NA | Sanofi-Aventis |
| The Genetic Basis of Atrial Fibrillation (AF) (web link) | NA | Recruiting | Atrial Fibrillation | NA | NA | University of Pittsburgh EP Research funds |
| Video-Assisted Thoracoscopic Pulmonary Vein Isolation Versus Percutaneous Catheter Ablation in Atrial Fibrillation Trial (VATCAT) (web link) | Procedure | Recruiting | Atrial Fibrillation | PVI | VATS-PVI | Medisch Spectrum Twente |
| Inflammation as a Predictor in Cardioversion of Atrial Fibrillation (web link) | Procedure | Recruiting | Atrial Fibrillation | Cardioversion | NA | Creighton University |
| Safety Monitoring of Patients Having Pulmonary Vein Ablation (ROTEA) (web link) | Unknown | Atrial Fibrillation | NA | NA | The Cleveland Clinic | |
| AMAZING PRAGUE (PRAGUE-12) (web link) | Procedure | Enrolling by invitation | Atrial Fibrillation Restore of Sinus Rhythm Post-Operative Complications | Cox-MAZE III | NA | Charles University, Czech Republic |
| Effect of Amiodarone on the Procedure Outcome in Long-standing Persistent Atrial Fibrillation Undergoing Pulmonary Vein Antral Isolation (SPECULATE) (web link) | Drug | Recruiting | Atrial Fibrillation | Amiodarone (Phase III) | NA | Texas Cardiac Arrhythmia Research Foundation |
| Effectiveness of Pulmonary Vein Isolation in Prevention of Atrial Fibrillation Following Heart Bypass Surgery (web link) | Device | Recruiting | Atrial Fibrillation | PVI with Medtronic's Cardioblate BP2 radiofrequency catheter (Phase III) | NA | Lawson Health Research Institute Medtronic |
| Effect of Addition of Dronedarone to Standard Rate Control Therapy on Ventricular Rate During Persistent Atrial Fibrillation (AFRODITE) (web link) | Drug | Active, not recruiting | Atrial Fibrillation | Dronedarone (Phase IV) | Beta blocker or calcium antagonist or digoxin | Sanofi-Aventis |
| Ibutilide Administration During Pulmonary Vein Ablation (web link) | Drug | Recruiting | Atrial Fibrillation Pulmonary Vein Ablation | Ibutilide fumarate | NA | Ball Memorial Hospital St. Jude Medical |
| Routine Versus Aggressive Upstream Rhythm Control for Prevention of Early Atrial Fibrillation in Heart Failure (RACE 3) (web link) | Other | Recruiting | Atrial Fibrillation | Upstream therapy | Conventional rhythm control | University Medical Centre Groningen |
| Efficacy and Safety Study on Agilis NxT Introducer in AF Patients (web link) | Procedure | Recruiting | Atrial Fibrillation | left atrial catheter ablation guided by introducer | NA | St. Jude Medical |
| Catheter Ablation of Atrial Fibrillation Using Hansen Medical Robotic Navigation (web link) | Procedure | Recruiting | Atrial Fibrillation | catheter ablation (Phase IV) | N/A | Barts & The London NHS Trust |
| Use of Fish Oils to Reduce the Frequency and Duration of Episodes of Atrial Fibrillation in Patients With Paroxysmal Atrial Fibrillation. (web link) | Drug | Recruiting | Atrial Fibrillation | Fish oil | NA | Melbourne Health |
| Optimal Timing of Dronedarone Initiation After Conversion in Patients With Persistent Atrial Fibrillation (ARTEMIS Load) (web link) | Drug | Recruiting | Atrial Fibrillation | DRONEDARONE (Phase IV) | N/A | Sanofi-Aventis |
| Atrial Fibrillation Ablation and Autonomic Modulation Via Thorascopic Surgery (AFACT) (web link) | Procedure | Recruiting | Atrial Fibrillation | Totally Thoracoscopic PV isolation | N/A | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) |
| HIFU Application in the Surgical Treatment of AF (web link) | Device | Enrolling by invitation | Atrial Fibrillation | Epicor Cardiac Ablation System | Procedure: Surgical ablation of permanent AF | St. Jude Medical |
| Assessing Arrhythmias After Ablation Using Implantable Recorders (REVEAL) (web link) | Device | Recruiting | Atrial Fibrillation | Reveal XT implantable loop recorder | N/A | University of Pennsylvania |
| Markers of Oxidative Stress Present in Blood in Patients With Atrial Fibrillation (web link) | NA | Recruiting | Atrial Fibrillation Inflammation Atrial Flutter | NA | NA | Emory University |
| Atrial Fibrillation Ablation on Gastric Motility (web link) | Procedure | Recruiting | Atrial Fibrillation Ablation Procedure | GI procedures | NA | University of Kansas |
| Randomized Trial of Two Ablation Catheters in Paroxysmal Atrial Fibrillation (web link) | Procedure | Recruiting | Atrial Fibrillation | WACA and PVI (Phase IV) | PVAC | University College London Hospitals |
| Study Comparing Pulmonary Vein Isolation With the Cryoballoon, Radiofrequency Energy, or Both in the Treatment of Atrial Fibrillation (AF) (Cryo Vs RFA) (web link) | Procedure | Recruiting | Atrial Fibrillation | Atrial fibrillation ablation | N/A | Barts & The London NHS Trust |
| PROTECT AF - WATCHMAN Left Atrial Appendage System for Embolic PROTECTion in Patients With Atrial Fibrillation (web link) | Device | Recruiting | Atrial Fibrillation Stroke | WATCHMAN Left Atrial Appendage System (Phase II|Phase III) | NA | Atritech |
| The Effect of Losartan on Atrial Fibrillation (AF) Burden and Pacemaker Dependence in Patients With Sick Sinus Syndrome (web link) | Drug | Recruiting | Atrial Fibrillation | Losartan | Placebo | Chung Shan Medical University |
| Atrial Fibrillation (AF) Patients Not Taking Vitamin-K Antagonist (VKA) (web link) | Drug | Active, not recruiting | Persistent or Permanent Non-Valvular Atrial Fibrillation | AZD0837 (Phase II) | Aspirin | AstraZeneca |
| Warfarin - How Good Are we at Maintaining Target Range ? (web link) | N/A | Active, not recruiting | Atrial Fibrillation | N/A | N/A | University of Dundee |
| Use of Fish Oils to Reduce Recurrence of Atrial Fibrillation Following DC Cardioversion (web link) | Drug | Recruiting | Atrial Fibrillation | Fish oil | NA | Melbourne Health |
| Clinical Study of the CardioFocus Endoscopic Ablation System - Adaptive Contact (CFEAS- AC) for the Treatment of Symptomatic Atrial Fibrillation (web link) | Device | Active, not recruiting | Paroxysmal Atrial Fibrillation | CardioFocus EAS-AC (Phase III) | NA | CardioFocus |
| Catheter Ablation Versus Thoracoscopic Ablation to Patients With Permanent Atrial Fibrillation (web link) | Procedure | Recruiting | Atrial Fibrillation | Catheter ablation | Thoracoscopic epicardial ablation | Rigshospitalet, Denmark |
| Pulmonary Vein (PV) -Isolation: Arrhythmogenic Vein(s) Versus All Veins (PAVAV) (web link) | Procedure | Unknown | Atrial Fibrillation | "Segmental PV-Isolation of the arrhythmogenic vein(s) (Phase IV) | Segmental PV-Isolation of all veins | Deutsches Herzzentrum Muenchen |
| NAVISTAR® THERMOCOOL® Catheter for the Treatment of Atrial Fibrillation (web link) | Device | Recruiting | Heart Diseases Arrhythmia Atrial Fibrillation | NAVISTAR® THERMOCOOL® catheter (Phase III) | NA | Biosense Webster, Inc. |
| Cryptogenic Stroke and Atrial Fibrillation Detection Through Implantable Loop Recorder (ILR)" (CRYPTONITE) (web link) | N/A | Recruiting | Atrial Fibrillation; Stroke | N/A | N/A | University of Valencia |
| Efficacy & Safety of Dronedarone Versus Amiodarone for the Maintenance of Sinus Rhythm in Patients With Atrial Fibrillation (web link) | Drug | Active, not recruiting | Atrial Fibrillation | dronedarone (SR33589) (Phase III) | amiodarone | Sanofi-Aventis |
| Studies of the Prevention of Atrial Fibrillation by ALA (web link) | Procedure | Unknown | Atrial Fibrillation Diet Therapy | ALA rich diet (Phase II) | NA | University of Toronto |
| A Phase III Study of Apixaban in Patients With Atrial Fibrillation (web link) | Drug | Recruiting | Atrial Fibrillation | Apixaban (Phase III) | Acetylsalicylic Acid (ASA) | Bristol-Myers Squibb Pfizer |
| Low Versus High Dose Magnesium Sulfate in the Early Management of Rapid Atrial Fibrillation (web link) | Drug | Unknown | Atrial Fibrillation | sulfate magnesium (Phase III) | magnesium sulfate | University of Monastir |
| Use of Fish Oils to Reduce the Frequency and Duration of Episodes of Atrial Fibrillation in Patients With Paroxysmal Atrial Fibrillation.Melbourne Health (web link) | Drug | Unknown | Atrial Fibrillation | Fish oil ( ) | N/A | Melbourne Health |
| The Maintenance of Human Atrial Fibrillation (web link) | N/A | Recruiting | Atrial Fibrillation; Arrhythmias Cardiac | N/A | N/A | University of California, San Diego |
| Pulmonary Vein (PV) -Isolation: Arrhythmogenic Vein(s) Versus All Veins (PAVAV) (web link) | Procedure | Unknown | Atrial Fibrillation | " Segmental PV-Isolation of the arrhythmogenic vein(s) (Phase IV) | Segmental PV-Isolation of all veins | Deutsches Herzzentrum Muenchen |
| Atrial Fibrillation Ablation and Autonomic Modulation Via Thorascopic Surgery (AFACT) (web link) | NA | Recruiting | Atrial Fibrillation | Totally Thoracoscopic PV isolation (Phase IV) | N/A | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) |
| Study to Determine the Efficacy of Perindopril to Prevent the Recurrence of Atrial Fibrillation in Patients With Essential Hypertension (web link) | Drug | Not yet recruiting | Essential Hypertension Atrial Fibrillation | Coversyl (perindopril) (Phase IV) | NA | Montreal Heart Institute Servier |
| Assessing Arrhythmias After Ablation Using Implantable Recorders (REVEAL) (web link) | Device | Recruiting | Atrial Fibrillation | Reveal XT implantable loop recorder (N/A ) | N/A | University of Pennsylvania |
| Markers of Oxidative Stress Present in Blood in Patients With Atrial Fibrillation (web link) | N/A | Unknown | Atrial Fibrillation; Inflammation; Atrial Flutter | N/A (Phase I) | N/A | Emory University |
| S.I.F.A. II: Prevention Of Thromboembolic Events In Patients With Nonrheumatic Atrial Fibrillation. (web link) | Drug | Active, not recruiting | Atrial Fibrillation | aspirin (Phase III) | indobufen | Pfizer |
| Asymptomatic Atrial Fibrillation and Stroke Evaluation in Pacemaker Patients and the Atrial Fibrillation Reduction Atrial Pacing Trial (web link) | Device | Recruiting | Hypertension Atrial Fibrillation | AF Suppression Pacing Algorithm (Phase IV) | NA | St. Jude Medical Population Health Research Institute |
| Atrial Fibrillation Ablation on Gastric Motility (web link) | Procedure | Recruiting | Atrial Fibrillation Ablation Procedure | GI procedures | N/A | University of Kansas |
| Study Comparing Pulmonary Vein Isolation With the Cryoballoon, Radiofrequency Energy, or Both in the Treatment of Atrial Fibrillation (AF) (Cryo Vs RFA) (web link) | Procedure | Recruiting | Atrial Fibrillation | Atrial fibrillation ablation ( Phase IV) | N/A | Barts & The London NHS Trust |
| Randomized Trial to Assess Efficacy of PUFA for the Maintenance of Sinus Rhythm in Persistent Atrial Fibrillation (web link) | Dietary Supplement | Not yet recruiting | Atrial Fibrillation | Omega 3 (n-3 PUFA) (Phase III) | Drug: Placebo | Fundacion GESICA |
| nContactSurgical Numeris-AF Tethered Coagulation System for Treatment of Longstanding Persistent Atrial Fibrillation (AF) (web link) | Device | Recruiting | Atrial Fibrillation | Numeris-AF Tethered Coagulation System with VisiTrax (nContact Surgical Inc) | N/A | |
| PV-Isolation: Arrhythmogenic Vein(s) vs. All Veins (web link) | Procedure | Recruiting | Atrial Fibrillation | Segmental PV-Isolation of the arrhythmogenic vein(s) (Phase IV) | Segmental PV-Isolation of all veins | Deutsches Herzzentrum Muenchen |
| Randomized Trial of Two Ablation Catheters in Paroxysmal Atrial Fibrillation (web link) | Device | Unknown | Atrial Fibrillation | WACA and PVI (Phase IV) | PVAC | University College London Hospitals |
| Atorvastatin Therapy for the Prevention of Atrial Fibrillation (SToP-AF) (web link) | Drug | Recruiting | Atrial Fibrillation Inflammation | 80 mg daily of atorvastatin (Phase II|Phase III) | NA | Emory University Pfizer |
| NAVISTAR® THERMOCOOL® Catheter for the Treatment of Atrial Fibrillation- TX (web link) | Device | Unknown | "Heart Diseases Arrhythmia Atrial Fibrillation" | Radiofrequency Ablation ( Phase III) | N/A | Biosense Webster, Inc |
| Effect of Corticosteroids on Atrial Fibrillation Incidence After Cardiac Surgery (web link) | Drug | Terminated | Atrial Fibrillation | intravenous hydrocortisone (Phase III) | NA | Kuopio University Hospital |
| WATCHMAN Left Atrial Appendage System for Embolic PROTECTion in Patients With Atrial Fibrillation (web link) | Device | Active, not recruiting | "Atrial Fibrillation Stroke" | WATCHMAN Left Atrial Appendage Closure Technology (Phase II) | N/A | Atritech |
| Use of Fish Oils to Reduce Recurrence of Atrial Fibrillation Following DC Cardioversion (web link) | Drug | Unknown | "Atrial Fibrillation " | Fish oil | N/A | Melbourne Health |
| Diastolic Dysfunction and Atrial Fibrillation in CABG Surgery (web link) | Procedure | Recruiting | Heart Disease Atrial Fibrillation | Diastolic measurements during TEE | NA | University Health Network, Toronto |
| Management of New-Onset Postoperative Atrial Fibrillation (AF) Utilizing Insertable Cardiac Monitor Technology to Observe Recurrence of AF (Monitor AF) (web link) | N/A | Not yet recruiting | "Atrial Fibrillation Coronary Artery Disease Post Operative Arrythmia" | N/A | N/A | Emory University |
| Gene Expression Profiles in Patients With Permanent Atrial Fibrillation (AF) Versus Sinus Rhythm (SR) (web link) | N/A | Recruiting | "Mitral Regurgitation Atrial Fibrillation Sinus Rhythm" | N/A | N/A | Ankara University |
| Omega 3 Fatty Acid Efficiency for Prevention of Atrial Fibrillation After Coronary Artery Bypass Grafting (web link) | Drug | Recruiting | Ischemic Heart Disease; Atrial Fibrillation | Omega-3 fish oil emulsion (Omegaven) (Phase III) | Intralipid | Meshalkin Research Institute of Pathology of Circulation |
| Ablation vs Drug Therapy for Atrial Fibrillation - Pilot Trial (web link) | Drug | Recruiting | Atrial Fibrillation Arrhythmia Stroke Prevention Mortality | Pharmacologic Therapy Rate and/or Rhythm Control (Phase III) | Device: NAVI-STAR Thermo-cool (Left Atrial Catheter Ablation) | Mayo Clinic Duke University St. Jude Medical |
| International Registry on Cardioversion of Atrial Fibrillation (MK-6621-051) (RHYTHM-AF) (web link) | NA | Recruiting | Atrial Fibrillation | NA (NA) | NA | Merck |
| (web link) | Device | Active, not recruiting | "Atrial Fibrillation Stroke " | WATCHMAN Left Atrial Appendage Closure Technology ( Phase II) | N/A | Atritech |
| (web link) | Drug | Recruiting | Ischemic Heart Disease; Atrial Fibrillation | Omega-3 fish oil emulsion (Omegaven) (Phase III) | Intralipid | Meshalkin Research Institute of Pathology of Circulation |
| Atrial Fibrillation: Ablation or Surgical Treatment II: FAST II (web link) | Procedure | Recruiting | Paroxysmal Atrial Fibrillation | Percutaneous radiofrequency catheter ablation (NA) | Mini invasive thoracoscopic radiofrequency ablation | Aalborg Hospital |
| Improving the quality of care for atrial fibrillation by promoting Patient-centered Decision Making (web link) | Behavioural | Active, Recruiting | Atrial Fibrillation | Decision Aid for Atrial Fibrillation(Phase I) | NA | VA Connecticut Health care System |
| Study of Ablation Versus antiarrhythmic Drugs in Persistent Atrial Fibrillation (web link) | Procedure | Active, Recruiting | Persistant Atrial Fibrillation | Atrial fibrillation ablation(Phase IV) | Antiarrhythmic drug | Hospital Clinic of Barcelona Medtronic Fundacio Clinic Biosense Webster, Inc." International Registry on Cardioversion of Atrial Fibrillation(2010-025)(RHYTHM-AF),Observational,"Active, Recruiting |
| Clinical effect of Heart Failure Management Via Home Monitoring With a Focus on Atrial Fibrillation (effect) (web link) | Device | Active, Recruiting | Atrial Fibrillation Heart failure | Home Monitoring (Cardiac resynchronization therapy and atrial fibrillation therapy with home monitoring feature) | Home Monitoring (Cardiac resynchronization therapy and atrial fibrillation therapy,without home monitoring) | Biotronik SE & Co. KG |
| Atrial Fibrillation After Cardiac Surgery-comparing Conventional and Miniaturized Bypass Systems (web link) | Procedure | Active, Recruiting | Atrial Fibrillation | Miniaturized bypass system | NA | Kuopio University Hospital University of Eastern Finland |
| The Assessment of Oxidative Stress Markers and the Development of Atrial Fibrillation After Cardiac Surgery (web link) | Observational | Active, Recruiting | Atrial Fibrillation | Observational | NA | University of Illinois |
| Benefit of Complex Fractionated Atrial Electrograms Elimination in Atrial Fibrillation Ablation (web link) | Device | Active, Recruiting | Atrial Fibrillation | Additional Complex Fractionated Electrograms ablation(Phase III) | Standard atrial fibrillation ablation procedure | Hospital Clinic of Barcelona Fundacio Clinic |
| Implantable Loop Recorder Versus Conventional Ambulatory Monitoring in Detecting Atrial Fibrillation After Pulmonary Vein Isolation (web link) | Device | Active, Recruiting | Atrial Fibrillation | Device: Implantable loop recorder (ILR) | NA | Odense University Hospital |
| 30-Day Cardiac Event Monitor Belt for Recording Atrial Fibrillation After a Cerebral Ischemic Event (web link) | Device | Active, Recruiting | Atrial Fibrillation Stroke | a 30-day ambulatory cardiac event monitor | NA | Sunnybrook Health Sciences Centre |
| The Effect of Short Term Amiodarone Treatment After Catheter Ablation for Atrial Fibrillation (web link) | Drug | Active, Recruiting | Atrial Fibrillation | Catheter ablation | Amiodarone | Rigshospitalet, Denmark" Dynamics of Human Atrial Fibrillation,Observational,"Active, Recruiting |
| A Study of the Efficacy and Safety of Vernakalant Hydrochloride (MK-6621) in Patients With Atrial Fibrillation (MK-6621-010) (web link) | Drug | Active, Recruiting | Atrial Fibrillation | vernakalant hydrochloride(Phase III) | Placebo to vernakalent hydrochloride | Merck |
| Prophylaxis to Reduce Postoperative Atrial Fibrillation in Cardiac Surgery (web link) | Drug | Active, Recruiting | Atrial Fibrillation | Beta blockers,amiodarone,ascorbic acid(Phase III) | NA | Maine Medical Center |
| Dual Epicardial Endocardial Persistent Atrial Fibrillation (AF) Study (web link) | Procedure | Active, Recruiting | Persistant Atrial Fibrillation | Hybrid ablation procedure(Phase II) | NA | AtriCure, Inc." Omega-3 Fatty Acids for Prevention of Post-Operative Atrial Fibrillation,Drug,"Active, Recruiting |
| Node and Atrial Fibrillation Ablation for Persistent Atrial Fibrillation (web link) | Device | Active, Recruiting | Persistant Atrial Fibrillation | AF ablation and AV node ablation | AV node ablation | Eastbourne General Hospital |
| Blood Pressure Assessment in Atrial Fibrillation (web link) | Observational | Active, not Recruiting | Atrial Fibrillation | Observational | NA | University of Athens |
| Screening for Atrial Fibrillation, After Ischemic Stroke (web link) | Observational | Active,Recruiting | Atrial Fibrillation Stroke | Observational | NA | Karolinska Institutet |
| Catheter Ablation Versus Medical Rate Control for Atrial Fibrillation in Patients With Heart Failure (web link) | Drug,Device | Active,Recruiting | Atrial Fibrillation Heart Failure | Medication to control ventricular rate in AF,Catheter Ablation for Persistent Atrial Fibrillation | NA | Royal Brompton & Harefield NHS Foundation Trust |
| Comparison of External Event Recorders for Atrial Fibrillation Monitoring (web link) | Device | Active,not Recruiting | Atrial Fibrillation | Standard Event Monitor | Sleuth Monitor | University of Kansas |
| Implanted Loop Recorder Post Atrial Fibrillation Ablation (web link) | Observational | Active,Recruiting | Atrial Fibrillation | Observational | NA | Thoracic & Cardiovascular Healthcare Foundation |
| Amiodarone Prophylaxis for Atrial Fibrillation in Patients Undergoing Surgery for Lung Cancer (web link) | Drug | Not Yet Recruiting | Atrial Fibrillation | Amiodarone | NA | Aarhus University Hospital |
| Atrial Electromechanical Interval and Pulse Wave Velocity in the Prediction of Recurrence of Atrial Fibrillation (web link) | Observational | Active,Recruiting | Atrial Fibrillation | Observational | NA | Creighton University |
| Radiofrequency Ablation of Atrial Fibrillation Under Totally Thoracoscope (web link) | Device | Active,Recruiting | Atrial Fibrillation | Epicardial radiofrequency ablation | NA | Xijing Hospital |
| Yoga on Arrhythmia Burden and Quality of Life in Paroxysmal Atrial Fibrillation (web link) | NA | Active,Recruiting | Atrial Fibrillation | Yoga Training | NA | University of Kansas |
| Postoperative New-onset Atrial Fibrillation in Cardiac Surgery: DECS-PNAF Project (web link) | Drug | Not Yet Recruiting | Atrial Fibrillation Cardiac Surgery | Dexamethasone(Phase IV) | Placebo | UMC Utrecht |
| SOLAR & ATRILAZE Atrial Fibrillation Trial (web link) | Device | Not Yet Recruiting | Atrial Fibrillation | Laser MAZE by Ablation of Cardiac Tissue(Phase III) | NA | EndoPhotonix, Inc. |
| Mesh Ablator Versus Cryoballoon Pulmonary Vein Ablation of Symptomatic Paroxysmal Atrial Fibrillation (web link) | Device | Active,Recruiting | Symptomatic Paroxysmal Atrial Fibrillation | Arctic Front® catheter vs. HD Mesh Ablator® catheter(Phase IV) | NA | Charite University, Berlin, Germany |
| Atrial Fibrillation Registry for Ankle-brachial Index Prevalence Assessment: Collaborative Italian Study (web link) | Observational | Active,Recruiting | Atrial Fibrillation Peripheral Vascular Disease | Observational | NA | University of Roma La Sapienza |
| NAVISTAR® THERMOCOOL® Catheter for the Radiofrequency Ablation of Drug Refractory Recurrent Symptomatic Paroxysmal Atrial Fibrillation (web link) | Procedure | Active,Recruiting | Paroxysmal Atrial Fibrillation | Atrial Fibrillation ablation procedure(Phase IV)NAVISTAR THERMOCOOL and NAVISTAR EZ STEER THERMOCOOL | NA | Biosense Webster, Inc |
| Clinical Study of the CardioFocus Endoscopic Ablation System - Adaptive Contact (EAS-AC) for the Treatment of Symptomatic Atrial Fibrillation (web link) | Device | Active,Recruiting | Paroxysmal Atrial Fibrillation | CardioFocus Endoscopic Ablation System - Adaptive Contact (EAS-AC)(Phase II) | NA | CardioFocus |
| Stepwise Approach Versus Linear Ablation in Patients With Recurrence of Persistent Atrial Fibrillation (web link) | Procedure | Active,Recruiting | Persistant Atrial Fibrillation | Ablation with stepwise approach | Linear ablation | Deutsches Herzzentrum Muenchen |
| Remote Ischemic Conditioning and Atrial Fibrillation After Coronary Artery Bypass Grafting (CABG) (web link) | Procedure | Enrolling by Invitation | Atrial Fibrillation | Remote ischemic conditioning(Phase II) | Sham | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) |
| Vitamin C for Prophylaxis of Post-operative Atrial Fibrillation in On-pump Cardiac Surgery Procedures (web link) | Drug | Active, not recruiting | Atrial Fibrillation | Vitamin C(Phase II) | NA | Attikon Hospital |
| Spanish Atrial Fibrillation And Resynchronization Study (web link) | Device | Not Yet Recruiting | Chronic Heart Failure Atrial Fibrillation Dilated Cardiomyopathy | Atrio ventricular junction ablation with radio-frequency | Beta blocker/digoxine/amiodarone | Hospital Clinic of Barcelona University of Navarrra Hospital (Clinica Universitaria) Fundación para la Investigación del Hospital Clínico de Valencia Puerta de Hierro University Hospital Hospital Universitario Ramon y Cajal Hospital Universitario La Fe Ho |
| Combined Treatment of Resistant Hypertension and Atrial Fibrillation (web link) | Procedure | Active,Recruiting | Resistant Hypertension Atrial Fibrillation | Circumferential PV isolation(Phase III) | Circumferential PV isolation PLUS renal denervation | Meshalkin Research Institute of Pathology of Circulation |
| Totally Endoscopic Ablation of Atrial Fibrillation (web link) | Device | Active,Recruiting | Atrial Fibrillation | Endoscopic ablation of AF | Rate control | University Hospital Orebro,Medtronic" The Effect of Atrial Fibrillation Hemodynamics on Regulation of Cerebral Blood Flow,Device,"Active,Recruiting |
| Antiarrhythmic Therapy Versus Catheter Ablation for Atrial Fibrillation in Hypertrophic Cardiomyopathy (web link) | Device | Active,Recruiting | Atrial Fibrillation Hypertrophic Cardiomyopathy | RF catheter ablation(Phase III) | Antiarrhythmic drugs | Institute of Cardiology, Warsaw, Poland" The Value of add-on Arrhythmia Surgery in Patients With Atrial Fibrillation Undergoing Cardiac Surgery,Procedure,Completed,Atrial Fibrillation,pulmonary vein isolation,NA, Maastricht University Medical Center Cor |
| Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF) (web link) | Observational | Active,Recruiting | Atrial Fibrillation | Observational | NA | Ortho-McNeil Janssen Scientific Affairs, LLC Duke University" Randomized Trial of Segmental Versus Circumferential Antral Ablation in Paroxysmal Atrial Fibrillation,Device,"Active,Recruiting |
| Cardiac Monitoring of Post-Operative Cancer Patients Experiencing Atrial Fibrillation (web link) | Behavioural | Active,Recruiting | Post-Operative Cancer Patients Experiencing Atrial Fibrillation | questionnaire about the use of ECG device | NA | Memorial Sloan-Kettering Cancer Center |
| "UNMASKING Study" For Atrial Fibrillation Recurrences Typing in Early Postoperative Period (web link) | Device | Active,Recruiting | Atrial Fibrillation | Circumferential pulmonary veins (PV) isolation and subcutaneous cardiac monitor implantation(Phase III) | NA | Meshalkin Research Institute of Pathology of Circulation |
| Atrial Fibrillation/Flutter Outcome Risk Determination (web link) | Observational | Active,Recruiting | Atrial Fibrillation Atrial Flutter | Observational | NA | Vanderbilt University,National Heart, Lung, and Blood Institute (NHLBI)" Intravenous Administration of Metoprolol Versus Biatrial Pacing in the Prevention of Atrial Fibrillation After Cardiac Surgery,"Device,Drug |
| Surgical Ablation Versus No Surgical Ablation for Patients With Atrial Fibrillation Undergoing Mitral Valve Surgery (web link) | Procedure | Active,Recruiting | Atrial Fibrillation Mitral Valve Insufficiency Mitral Valve Stenosis | Mitral valve surgery with ligation/excision of left atrial appendage with ablation(Phase II) | Mitral valve surgery with ligation/excision of left atrial appendage | National Heart, Lung, and Blood Institute (NHLBI) National Institute of Neurological Disorders and Stroke (NINDS) Canadian Institutes of Health Research (CIHR)" Intravenous Metoprolol Versus Intravenous Amiodarone in the Prevention of Atrial Fibrillation |
| Gene Expression Profiling in Subjects With Postoperative Atrial Fibrillation After Cardiac Surgery (web link) | Observational | Acive,Recruiting | Atrial Fibrillation | Atrial biopsy | NA | Brigham and Women's Hospital |
| DECAAF: Delayed-Enhancement MRI (DE-MRI) Determinant of Successful Radiofrequency Catheter Ablation of Atrial Fibrillation (web link) | Observational | Enrolling by invitation | Atrial Fibrillation | DE-MRI | NA | University of Utah |
| Prevention of Atrial Fibrillation by Inhibition Conversion Enzyme (ICE) After Radiofrequency Ablation of Atrial Flutter (web link) | Drug | Acive,Recruiting | Atrial Fibrillation Atrial Flutter | Ramipril(Phase III) | Placebo | Centre Hospitalier Universitaire de Saint Etienne Sanofi-Aventis Ministry of Health, France Sorin Group" Medical Economical Evaluation of the Ablation by Catheter of the Atrial Tissue in the Treatment of AF,Observational,"Active, not recruiting |
| Full Disclosure Observational Cardiac Rhythm Documentation Follow-up After Surgical Atrial Fibrillation Therapy (web link) | Observational | Acive,Recruiting | Atrial Fibrillation | Cardiac rhythm monitor implantation.Device: Reveal® XT 9525 | NA | University of Luebeck |
| Dronedarone in Pacemakers Patients With Paroxysmal Atrial Fibrillation (web link) | Drug | Not yet recruiting | Paroxysmal Atrial Fibrillation | Dronedarone(Phase IV) | Placebo | Eastbourne General Hospital |
| Safety and Efficacy Study of the Combined Ablation Procedure to Treat Paroxysmal Atrial Fibrillation (web link) | Procedure | Acive,Recruiting | Paroxysmal Atrial Fibrillation | Numeris®-AF Guided Coagulation System with VisiTrax® | NA | nContact Surgical Inc |
| Visualization and Structured Attention Behaviour for Pain and Anxiety Reduction During Ablation of Atrial Fibrillation (web link) | Behavioural | Active, not recruiting | Atrial Fibrillation | visualization together with structured behavioural attention. | NA | Rigshospitalet, Denmark" Efficiency of Radiofrequency Ablation for Surgical Treatment of Chronic Atrial Fibrillation With Rheumatic Valve Disease,Device,"Acive,Recruiting |
| Incidence of Atrial Fibrillation in Patients With Severe Obstructive Sleep Apnea: The Reveal XT-SA Study (web link) | Device | Not yet recruiting | Obstructive Sleep Apnea Atrial Fibrillation | Implantable Loop Recorder Insertion | NA | Queen's University Medtronic |
| Evaluation Of New Onset Postoperative Atrial Fibrillation (web link) | Device | Not yet recruiting | Atrial Fibrillation | Device: CorMatrix® ECM™ for Pericardial Closure | NA | CorMatrix Cardiovascular, Inc." Magnesium Sulphate for Treatment of New Onset Atrial Fibrillation in Medical Intensive Care Unit Patient,Drug,"Active,Recruiting |
| Selective Complex Fractionated Atrial Electrograms (CFAE) Targeting for Atrial Fibrillation (web link) | Device | Active, not recruiting | Atrial Fibrillation | CFAE ablation(Phase IV) | NA | Biosense Webster, Inc." Atrial Fibrillation Ablation Pilot Study,Procedure,Completed,Atrial Fibrillation,Ablation procedure and/or cardioversion(Phase I),NA,Ablation Frontiers Pulmonary Vein (PV) Isolation Versus Box Isolation for the Treatment of Atria |
| Comparison of Externally Versus Internally Cooled Tip Catheter Ablation in Paroxysmal Atrial Fibrillation (web link) | Procedure | Active,Recruiting | Atrial Fibrillation | Long-term electrical isolation of pulmonary veins | NA | University Hospital, Bordeaux Boston Scientific Corporation" Alster Man and Machine: Comparison of Manual and Mechanical Remote Robotic Catheter Ablation for Drug-Refractory Atrial Fibrillation,Procedure,"Active,Recruiting |
| Safety and Efficacy Study of The Combined Ablation Procedure To Treat Longstanding Persistent Atrial Fibrillation (web link) | Device | Active,Recruiting | Atrial Fibrillation | Device: Numeris®-AF Guided Coagulation System with VisiTrax® | NA | nContact Surgical Inc. |
| PAF-HEFT (Permanent Atrial Fibrillation in Heart Failure Trial) (web link) | Procedure | Active,Recruiting | Atrial Fibrillation Heart Failure | Ablation(Phase IV) | Rate Control | Medtronic Bakken Research Center Medtronic |
| Modified Ablation Guided by Ibutilide Use in Chronic Atrial Fibrillation (web link) | Drug | Active,Recruiting | Persistant Atrial Fibrillation | Ibutilide | Placebo | Mount Sinai School of Medicine St. Jude Medical |
| Effects of Dronedarone on Atrial Fibrillation Burden in Subjects With Permanent Pacemakers (web link) | Drug | Active,Recruiting | Atrial Fibrillation | Dronedarone(Phase IV) | Placebo | Sanofi-Aventis |
| Discerning Symptomatic and Asymptomatic Episodes Pre and Post Radiofrequency Ablation of Atrial Fibrillation (web link) | Device | Active, not recruiting | Atrial Fibrillation | Device: Implantable Loop Recorder (ILR) | NA | University of Ottawa Heart Institute Medtronic |
| Homeopathy for Prevention of Atrial Fibrillation After Aortocoronary Bypass Surgery (web link) | Drug | Active,Recruiting | Atrial Fibrillation | Nux vomica (active comparator) | Placebo (placebo comparator) | Medical University of Vienna |
| Post-Market Clinical Study of the CardioFocus Endoscopic Ablation System - Adaptive Contact (CF-EAS-AC) for the Treatment of Symptomatic Atrial Fibrillation (web link) | Procedure | Active,Recruiting | Atrial Fibrillation | Endoscopically Guided Ablation (Phase IV) | NA | CardioFocus |
| Repeat Ablation Procedure in Patients With Relapse of Atrial Fibrillation (web link) | Procedure | Active,Recruiting | Paroxysmal Atrial Fibrillation | Ablation | NA | Deutsches Herzzentrum Muenchen |
| A Multicenter Data Registry for Outcomes From Surgical Treatment of Atrial Arrhythmias (web link) | Observational | Active,Recruiting | Atrial Fibrillation | Minimally Invasive Maze Procedure | NA | Virginia Commonwealth University AtriCure, Inc." The Role of Cardiac Biomarkers in Prediction of Outcome in Atrial Fibrillation Patients Undergoing Catheter Ablation,Observational,"Active,Recruiting |
| Ablation vs Amiodarone for Treatment of AFib in Patients With CHF and an ICD (web link) | Procedure | Active,Recruiting | Heart Failure Atrial Fibrillation | Atrial fibrillation ablation(Phase IV) | Amiodarone | Texas Cardiac Arrhythmia Research Foundation Casa Sollievo della Sofferenza IRCCS Catholic University, Italy Southlake Regional Health Centre Stanford University University of Kansas The University of Texas, Galveston University of Foggia Sutter Health" |
| Prospective, Multi Centre, International Registry of Male and Female Patients Newly Diagnosed With Atrial Fibrillation (web link) | Observational | Active,Recruiting | Persistant Atrial Fibrillation | Observational | NA | Thrombosis Research Institute Bayer |
| Omega 3 Fatty Acid Efficiency for Prevention of Atrial Fibrillation After Coronary Artery Bypass Grafting (web link) | Drug | Active,Recruiting | Ischemic Heart Disease Atrial Fibrillation | Omega-3 fish oil emulsion (Omegaven)(Phase III) | Intralipid | Meshalkin Research Institute of Pathology of Circulation |
| Ablation of the Pulmonary Veins for Paroxysmal Afib (web link) | Procedure | Active,not Recruiting | Paroxysmal Atrial Fibrillation | RF Ablation procedure (Phase IV) | NA | Ablation Frontiers |
| Gene Expression Profiles in Patients With Permanent Atrial Fibrillation (AF) Versus Sinus Rhythm (SR) (web link) | Observational | Active,Recruiting | Atrial Fibrillation | Observational | NA | Ankara University,Tubitak" NAVISTAR® THERMOCOOL® Catheter for the Treatment of Atrial Fibrillation- TX,Device,"Active,not Recruiting |
| nContactSurgical Numeris-AF Tethered Coagulation System for Treatment of Longstanding Persistent Atrial Fibrillation (AF) (web link) | Device | Active,Recruiting | Atrial Fibrillation | Numeris-AF Tethered Coagulation System with VisiTrax | NA | nContact Surgical Inc. |
| Assessing Arrhythmias After Ablation Using Implantable Recorders (web link) | Device | Active,Recruiting | Atrial Fibrillation | Reveal XT implantable loop recorder | NA | University of Pennsylvania Medtronic |
| Atrial Fibrillation Ablation and Autonomic Modulation Via Thorascopic Surgery (web link) | Procedure | Active,Recruiting | Atrial Fibrillation | Totally Thoracoscopic PV isolation(Phase IV) | NA | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) Netherlands Heart Foundation |
| The Maintenance of Human Atrial Fibrillation (web link) | Observational | Active,Recruiting | Atrial Fibrillation | Observational | NA | University of California, San Diego National Institutes of Health (NIH)" "Efficacy, Safety and Efficiency Study of CARTO® 3 System Guided THERMOCOOL® Catheter Ablation Versus Fluoroscopy Guided Ablation With the Pulmonary Vein Ablation Catheter® (PVAC®) |
| Low Versus High Dose Magnesium Sulfate in the Early Management of Rapid Atrial Fibrillation (web link) | Drug | Not yet recruiting | Atrial Fibrillation | magnesium sulfate(Phase III) | NA | University of Monastir |
| "Cryptogenic Stroke and Atrial Fibrillation Detection Through Implantable Loop Recorder (ILR)" (web link) | Observational | Active,Recruiting | Atrial Fibrillation | Observational | NA | University of Valencia Hospital Universitario Virgen de la Arrixaca Universidad de Murcia |
| Continued Access Protocol (web link) | Device | Enrolling by invitation | Atrial Fibrillation | Arctic Front Cardiac Cryoablation System | NA | CryoCath Technologies Inc. Medtronic |
| Efficacy and Safety Study of Catheter Ablation for Atrial Fibrillation (web link) | Procedure | Active,Recruiting | Atrial Fibrillation | catheter ablation(Phase IV) | NA | Wuhan University Peking Union Medical College Shanghai Chest Hospital Nanjing Medical University West China Hospital Guangdong General Hospital Dalian Medical University Capital Medical University |
| Evaluation of the WATCHMAN LAA Closure Device in Patients With Atrial Fibrillation Versus Long Term Warfarin Therapy (web link) | Device | Active,Recruiting | Atrial Fibrillation | WATCHMAN Device(Phase III) | Warfarin | Atritech |
| Evaluate Use of Mangosteen Juice Added to Usual Care in Reducing Risk of Recurrent Atrial Fibrillation (web link) | Drug | Active,Recruiting | Atrial Fibrillation | mangosteen juice(Phase I) | placebo juice | Mayo Clinic |
| Clinical Evaluation of Therapy™ Cool Flex Ablation Catheter for the Treatment of Paroxysmal Atrial Fibrillation (web link) | Device | Active,Recruiting | Paroxysmal Atrial Fibrillation | Therapy™ Cool Flex Ablation Catheter(Phase II) | NA | St. Jude Medical |
| Low Dose of Diltiazem for Rate Control of Atrial Fibrillation (web link) | Drug | Active,Recruiting | Atrial Fibrillation | low dose diltiazem(Phase IV) | NA | Seoul National University Hospital |
| Dose Ranging Study of Dronedarone for the Control of Ventricular Rate in Japanese Patients With Permanent Atrial Fibrillation (web link) | Drug | Active,Recruiting | Atrial Fibrillation | Dronedarone(Phase II) | Placebo | Sanofi-Aventis |
| Clinical Study of the CardioFocus Endoscopic Ablation System - Adaptive Contact (CFEAS- AC) for the Treatment of Symptomatic Atrial Fibrillation (web link) | Device | Active,Recruiting | Paroxysmal Atrial Fibrillation | CardioFocus EAS-AC(Phase III) | NA | CardioFocus |
| Catheter Ablation of Atrial Fibrillation Using Hansen Medical Robotic Navigation (web link) | Procedure | Active,not Recruiting | Atrial Fibrillation | catheter ablation(Phase IV) | NA | Barts & The London NHS Trust |
| Optimal Timing of Dronedarone Initiation After Conversion in Patients With Persistent Atrial Fibrillation (web link) | Drug | Active,Recruiting | Atrial Fibrillation | Dronedarone(Phase IV) | NA | Sanofi-Aventis |
| Routine Versus Aggressive Upstream Rhythm Control for Prevention of Early Atrial Fibrillation in Heart Failure (web link) | Other | Active,Recruiting | Atrial Fibrillation | Upstream therapy | Conventional rhythm control | University Medical Centre Groningen Netherlands Heart Foundation Interuniversity Cardiology Institute Netherlands Working group Cardiology Netherlands Trial Coordination Center UMC Groningen Sanofi-Aventis Boehringer Ingelheim Pharmaceuticals Medtronic Bi |
| Effect of Addition of Dronedarone to Standard Rate Control Therapy on Ventricular Rate During Persistent Atrial Fibrillation (AFRODITE) (web link) | Drug | Active,Recruiting | Atrial Fibrillation | Dronedarone(Phase IV) | Beta blocker or calcium antagonist or digoxin | Sanofi-Aventis |
| Effect of Amiodarone on the Procedure Outcome in Long-standing Persistent Atrial Fibrillation Undergoing Pulmonary Vein Antral Isolation (web link) | Drug | Active,Recruiting | Atrial Fibrillation | Amiodarone(Phase III) | NA | Texas Cardiac Arrhythmia Research Foundation University of Kansas California Pacific Medical Center Stanford University Case Western Reserve University Southlake Regional Health Centre Catholic University, Italy" Pharmacokinetics and Optimal Timing of Dr |
| Permanent Atrial fibriLLAtion Outcome Study Using Dronedarone on Top of Standard Therapy (web link) | Drug | Active,Recruiting | Atrial Fibrillation | Dronedarone (SR33589)(Phase III) | Placebo | Sanofi-Aventis |
| Warfarin - How Good Are we at Maintaining Target Range ? (web link) | Observational | Active,not Recruiting | Atrial Fibrillation | Observational | NA | University of Dundee NHS Tayside |
| Evaluate the Pharmacokinetics and Safety of MK-4448 in Participants With Nonvalvular Atrial Fibrillation (Study MK-4448-006) (web link) | Drug | Active,not Recruiting | Atrial Fibrillation | Amiodarone Group,Betrixaban 60 mg,Betrixaban 90 mg(Phase II) | NA | Merck Portola Pharmaceuticals |
| Effects of Dronedarone on Cardiac Geometry and Function in Patients With Atrial Fibrillation and Left Atrial Enlargement (web link) | Drug | Active,Recruiting | Atrial Fibrillation | Dronedarone (SR33589)(Phase IV) | Placebo | Sanofi-Aventis |
| Anticoagulation in Stent Intervention (web link) | Drug | Active,Recruiting | Atrial Fibrillation | Acetylsalicylic Acid (aspirin) + clopidogrel + acenocoumarol(Phase IV) | Acetylsalicylic Acid (aspirin) + clopidogrel | Hospital Universitari Vall d'Hebron Research Institute |
| ABLATE AF Registry Trial (web link) | Device | Active,Recruiting | Atrial Fibrillation | AtriCure Bipolar System(Phase III) | NA | AtriCure, Inc." A Prospective Randomized Study Comparing Radiofrequency Energy With Cryoenergy,Procedure,"Active,Recruiting |
| ASA Plavix Feasibility Study With WATCHMAN Left Atrial Appendage Closure Technology (web link) | Device | Active,Recruiting | Atrial Fibrillation | WATCHMAN | NA | Atritech |
| QT Variability Pre and Post Cardioversion (web link) | Observational | Active,Recruiting | Atrial Fibrillation | Observational | NA | Vanderbilt University National Institutes of Health (NIH) Wake Forest University |
| Left Atrial Appendage Occlusion Study II (web link) | Procedure | Active,Recruiting | Atrial Fibrillation | Surgical occlusion of the left atrial appendage(Phase III) | Best medical practice | Population Health Research Institute Canadian Network for Clinical Trials Internationally (CANNeCTIN) McMaster University University of Toronto University of Montreal University of Ottawa Heart Institute |
| Effects of Fish Oil on Post Ablation Arrhythmias (web link) | Drug | Active,Recruiting | Atrial Fibrillation | LOVAZA Omega 3-acid ethyl esters(Phase IV) | placebo | University of Michigan, Section of Electrophysiology (Arrhythmia Research) GlaxoSmithKline" Effect of Structural Remodeling on Scar Formation as Assessed by DE-MRI of the Left Atrium,Observational,Enrolling by invitation,Atrial Fibrillation,Observational |
| Oral Steroids Before Pulmonary Vein Isolation to Improve Outcomes (web link) | Drug | Active,Recruiting | Atrial Fibrillation | Ablation plus prednisone | Ablation plus placebo | University of Kansas |
| Role of Coumadin in Preventing Thromboembolism in Atrial Fibrillation (AF) Patients Undergoing Catheter Ablation (web link) | Drug | Active,Recruiting | Atrial Fibrillation | Coumadin(Phase III) | NA | Texas Cardiac Arrhythmia Research Foundation University of Kansas California Pacific Medical Center Stanford University Case Western Reserve University Southlake Regional Health Centre Catholic University, Italy" DU-176b Phase 2 Dose Finding Study in Sub |
| Ablation of Perimitral Flutter Following Catheter Ablation of Atrial Fibrillation: Impact on Outcomes (web link) | Procedure | Active,Recruiting | Atrial Fibrillation Perimitral Flutter | catheter ablation(Phase III) | NA | Texas Cardiac Arrhythmia Research Foundation |
| Substrate and Trigger Ablation for Reduction of Atrial Fibrillation Trial - Star AF II Study (web link) | Device | Active,Recruiting | Atrial Fibrillation | PVI + Lines ablation | PVI + CFE ablation | St. Jude Medical |
| Study of the Effects of Intravenous K201 on the Restoration of Sinus Rhythm in Subjects With Symptomatic Atrial Fibrillation (web link) | Drug | Not yet recruiting | Atrial Fibrillation | K201(Phase II) | saline | Sequel Pharmaceuticals, Inc" Secondary Prevention of Atrial Fibrillation (Impact of Renin-Angiotensin-Aldosterone System Inhibition),Drug,Enrolling by invitation,Atrial Fibrillation,cozaar(Phase IV),no drug,University of Pittsburgh Linear Ablation Versu |
| Study Comparing Pulmonary Vein Isolation With the Cryoballoon, Radiofrequency Energy, or Both in the Treatment of Atrial Fibrillation (AF) (web link) | Procedure | Active,Recruiting | Atrial Fibrillation | Atrial fibrillation ablation | NA | Barts & The London NHS Trust |
| The Use of Dual Chamber ICD With Special Programmed Features to Lower the Risk of Inappropriate Shock (web link) | Device | Active,not Recruiting | Atrial Fibrillation | ICD(Phase IV) | NA | Mayo Clinic Medtronic |
| RELY-ABLE Long Term Multi-center Extension of Dabigatran Treatment in Patients With Atrial Fibrillation Who Completed RE-LY Trial (web link) | Drug | Active,not Recruiting | Atrial Fibrillation | dabigatran dose 2(Phase III) | dabigatran dose 1 | Boehringer Ingelheim Pharmaceuticals |
| Corticosteroid Pulse After Ablation (web link) | Drug | Active,not Recruiting | Atrial Fibrillation | Solumedrol(Phase IV) | Placebo | Minneapolis Heart Institute Foundation St Jude Medical (grant) |
| Left Atrial Distensibility to Predict Left Ventricular Filling Pressure and Prognosis in Patients With Severe Mitral Regurgitation (web link) | Procedure | Active,Recruiting | Mitral Valve Insufficiency Atrial Fibrillation Heart Failure | Cardiac catheterization | NA | Kaohsiung Veterans General Hospital. National Science Council, Taiwan" Cytochrome P450 2D6 (CYP 450 2D6) Genotype and Flecainide Efficacy,Observational,Not yet recruiting,Atrial Fibrillation,Observational,NA,Assaf-Harofeh Medical Center Implantable Loop |
| Efficacy Study for Surgery After Previous Failed Catheter Ablation (web link) | Procedure | Active,not Recruiting | Atrial Fibrillation Ablation | Totally Thoracoscopic Maze | NA | Cardiopulmonary Research Science and Technology Institute AtriCure, Inc. Virginia Commonwealth University" Does Atorvastatin Prevent Post Operative Atrial Fibrillation After Pulmonary Resection: A Randomized Clinical Study,Drug,"Active,Recruiting |
| European Carto XP Registry for Validating Specialized CFAE Software(EXPRESSO) (web link) | Procedure | Active,Recruiting | Atrial Fibrillation | RF ablation, using specialized CFAE software | NA | Biosense Webster EMEA |
| Benefit of Left Atrial Roof Ablation in Paroxysmal Atrial Fibrillation (web link) | Procedure | Active,Recruiting | Drug-refractory Paroxysmal Atrial Fibrillation | Pulmonary vein encircling(Phase III) | Pulmonary vein encircling plus roof ablation | Hospital Clinic of Barcelona |
| Characterisation of Fractionated Electrograms Critical for Maintenance of Atrial Fibrillation (AF) (web link) | Procedure | Active,Recruiting | Atrial Fibrillation | catheter ablation | NA | Barts & The London NHS Trust |
| Surgical or Catheter Ablation of Lone Atrial Fibrillation (AF) Patients (web link) | Procedure | Active,Recruiting | Atrial Fibrillation | Catheter Ablation | Surgical Ablation | Medtronic Bakken Research Center |
| RECORD Asia-Pacific Atrial Fibrillation Registry (web link) | Observational | Active,Recruiting | Atrial Fibrillation | Observational | NA | Sanofi-Aventis |
| Evaluation of Fondaparinux in Patients With a Heart Rhythm Disturbance Who Undergo Restoration of Normal Heart Rhythm (web link) | Drug | Active,Recruiting | Atrial Fibrillation | fondaparinux(Phase II) | Vitamin-K-Antagonist | GlaxoSmithKline |
| Pulmonary Vein Isolation Outcomes With Fish Oils(PUFA) (web link) | Drug | Temporarily not available | Atrial Fibrillation | Lovaza (Fish Oils) | NA | St. Luke's-Roosevelt Hospital Center GlaxoSmithKline |
| Fish Oil Versus Statins Versus Placebos in Reducing Atrial Fibrillation in Patients Undergoing Thoracic Surgery for Lung Cancer (web link) | Drug | Not yet recruiting | Advanced Cancers | Atorvastatin|Dietary Supplement: Fish Oil Supplement(Phase III) | Placebo | M.D. Anderson Cancer Center |
| Prevalence of Primary Aldosteronism in Hypertensive Patients Presenting With Atrial Flutter or Fibrillation (web link) | Observational | Not yet recruiting | Atrial Fibrillation | Observational | NA | University Hospital Padova |
| Ablating Atrial Tachycardias Occuring During Ablation of Complex Fractionated Electrograms in Persistent AF (web link) | Procedure | Active,Recruiting | Atrial Fibrillation | Ablation | Cardioversion | Deutsches Herzzentrum Muenchen Klinik für Kardiologie, Klinikum Karlsruhe, Prof. Dr. C. Schmitt" Early Identification of Warfarin Maintenance Dosage,Genetic,"Active,Recruiting |
| AVAI: Atrial Ventricular Arrythmia Incidence (web link) | Observational | Active,Recruiting | Atrial Fibrillation : Ventricular Tachycardia | Observational | NA | St. Jude Medical |
| AMPLATZER Cardiac Plug Clinical Trial (web link) | Device | Active,Recruiting | Atrial Fibrillation | AMPLATZER Cardiac Plug(Phase I) | NA | AGA Medical Corporation |
| Dronedarone Pattern of Use in Patients Scheduled for Elective Cardioversion (ELECTRA) (web link) | Drug | Active,Recruiting | Atrial Fibrillation | Dronedarone(Phase IV) | Placebo | Sanofi-Aventis |
| Peri-operative Oral Triiodothyronine Replacement Therapy to Decrease the Risk of Transient Atrial Fibrillation After Off-pump Coronary Artery Bypass Surgery (web link) | Drug | Active,Recruiting | Coronary Artery Occlusive Disease | liothyronine sodium | NA | Yonsei University |
| Telemetric Arrhythmia and Syncope Diagnosis - Evaluation of Arrhythmia Treatment Efficacy (web link) | Device | Not yet recruiting | Atrial Fibrillation | Prolonged telemetric Full Disclosure ECG recording. | NA | Institute of Cardiology, Warsaw, Poland Medical University of Warsaw Medical University of Silesia" Identification of Genomic Predictors of Adverse Events After Cardiac Surgery,Device,"Active,Recruiting |
| Left Atrial Ablation With Permanent Pacemaker or ImplanTable Loop Recorder Follow-UP (web link) | Procedure | Not yet recruiting | Paroxysmal Atrial Fibrillation | AF Ablation with Ablation Frontiers Technology,: AF Ablation with LASSO catheter,Device: Reveal XT,Device: Permanent Dual Chamber Pacemaker | NA | Eastbourne General Hospital |
| Left Atrial Distensibility to Predict Prognosis in Consecutive Patients (web link) | Other | Active,Recruiting | Heart Failure Atrial Fibrillation Stroke | Echocardiography, including the measurements of left atrial (LA) distensibility | NA | Kaohsiung Veterans General Hospital |
| Effect of Balloon Cryoablation on Left Atrial Function (web link) | Device | Active,Recruiting | Atrial Fibrillation | Pulmonary vein isolation with cryoballoon catheter(Phase III) | NA | Reddy, Vivek Y., M.D." Study to Help Determine the Type of AF a Subject Has and Help Find the Best Medications for That Subject,Drug,Not yet recruiting,Atrial Fibrillation,Procainamide,NA,Vanderbilt University SOAR: Study Observing Antiarrhythmic Remode |
| OptiSense™ Performance in Detecting Atrial Episodes (web link) | Device | Active,Recruiting | Atrial Fibrillation | OptiSense Lead(Phase IV) | Tendril Lead | St. Jude Medical |
| Intravenous Lidocaine and Postoperative Outcomes After Cardiac Surgery (web link) | Drug | Active,Recruiting | Cardiac Surgery Atrial Fibrillation | Lidocaine | Placebo | Outcomes Research Consortium |
| PV-Isolation With the Cryoballoon Versus RF:a Randomized Controlled Prospective Non-inferiority Trial (FreezeAF) (web link) | Procedure | Active,Recruiting | Atrial Fibrillation | PV-Isolation RF(Phase IV) | PV-Isolation Cryo | Staedtisches Klinikum Karlsruhe University of Heidelberg |
| Study of Continuous Cardiac Monitoring to Assess Atrial Fibrillation After Cryptogenic Stroke (web link) | Device | Active,Recruiting | Cryptogenic Ischemic Stroke | Reveal® XT Insertable Cardiac Monitor(Phase IV) | NA | Medtronic Cardiac Rhythm Disease Management Medtronic Bakken Research Center |
| Adenosine Following Pulmonary Vein Isolation to Target Dormant Conduction Elimination: the ADVICE Trial (web link) | Procedure | Active,Recruiting | Paroxysmal Atrial Fibrillation Pulmonary Vein Isolation | Additional ablation until elimination of dormant conduction(Phase IV) | Usual medical care | Montreal Heart Institute |
| RATE Registry - Registry of Atrial Tachyarrhythmia/Atrial Fibrillation (AT/AF) Episodes in the Cardiac Rhythm Management (CRM) Device Population (web link) | Device | Active,Recruiting | Atrial Fibrillation | CRM Device | NA | St. Jude Medical |
| Measurement of Left and Right Atria From CT Scans of Cardiac Rhythm Disorder Cases (web link) | Other | Not yet recruiting | Atrial Fibrillation | Observational | NA | Kardium Inc. |
| Alster-Lost-AF-Study (web link) | Procedure | Active,Recruiting | Atrial Fibrillation | pulmonary vein isolation(Phase IV) | pulmonary vein isolation with additional ablation of fragmented potentials | Asklepios proresearch |
| A(f)MAZE-CABG Study (web link) | Device | Active,not Recruiting | Coronary Arteriosclerosis Atrial Fibrillation | HIFU AF Ablation | Best Medical Therapy | St. Jude Medical |
| Cryptogenic Stroke Study (web link) | Device | Active,Recruiting | Cryptogenic Stroke | Sleuth AT Implantable ECG Monitoring System | NA | Transoma Medical |
| Amiodarone Compared to Dronedarone , Post Cardioversion Maintenance of Sinus Rhythm (web link) | Drug | Not yet recruiting | Atrial Fibrillation | amiodarone | Dronedarone | Eastbourne General Hospital |
| Comparison of Two Potassium Targets Within the Normal Range in Intensive Care Patients (web link) | Drug | Active,Recruiting | Thoracic Surgery Cardiac Surgery Critically Ill | Potassium Chloride(Phase IV) | NA | University Medical Centre Groningen |
| Effect of Remote Ischemic Preconditioning on Cardiac Function After Cardiac Surgery (web link) | Procedure | Active,Recruiting | Atrial Fibrillation Ventricular Arrythmias Myocardial Injury | Remote Ischemic Preconditioning(Phase I) | Control/sham procedure | University of Schleswig-Holstein University Hospital, Frankfurt" Strategy of Early Detection and Active Management of Supraventricular Arrhythmia With Telecardiology (SETAM),Other,"Active,Recruiting |
| Cryoenergy Or Radiofrequency for Pulmonary Vein Isolation (web link) | Device | Active,Recruiting | Atrial Fibrillation | Pulmonary vein cryoablation(Phase IV) | Pulmonary vein radiofrequency ablation | Hospital San Carlos, Madrid Spanish Society of Cardiology" WOEST ( What is the Optimal antiplatelet & Anticoagulant Therapy in Patients With Oral Anticoagulation and Coronary StenTing),Device,"Active,Recruiting |
| Telemetric Arrhythmia Diagnosis in Adults (web link) | Device | Not yet recruiting | Atrial Fibrillation | Prolonged telemetric Full Disclosure ECG recording. | NA | Institute of Cardiology, Warsaw, Poland" An Interaction Study With Digoxin and AZD1305,Drug,Completed,Atrial Fibrillation,AZD1305(Phase I),Digoxin,AstraZeneca Data Collection and Analysis of Patients Who Have Had an Electrophysiological Procedure,Observ |
| EUropean Pharmacogenetics of AntiCoagulant Therapy - Warfarin(EU-PACT) (web link) | Other | Not yet recruiting | Venous Thromboembolism Atrial Fibrillation | Genotype-guided dosing algorithm(Phase IV) | Non-genotype-guided dosing algorithm | Utrecht Institute for Pharmaceutical Sciences Utrecht University Leiden University Medical Center Erasmus Medical Center University of Ulm Newcastle University University of Liverpool LGC Ltd. Hospital Sierrallana Uppsala University Democritus University |
| EUropean Pharmacogenetics of AntiCoagulant Therapy - Acenocoumarol(EU-PACT) (web link) | Other | Not yet recruiting | Venous Thromboembolism Atrial Fibrillation | Genotype-guided dosing algorithm(Phase IV) | Non-genotype-guided dosing algorithm | Utrecht Institute for Pharmaceutical Sciences Utrecht University Leiden University Medical Center Erasmus Medical Center University of Ulm Newcastle University University of Liverpool LGC Ltd. Hospital Sierrallana Uppsala University Democritus University |
| Long-term Cardiac Monitoring After Cryptogenic Stroke (CMACS) (web link) | Device | Active,Recruiting | Stroke | Cardionet Mobile Cardiac Outpatient Telemetry (MCOT)(Phase I) | NA | University of California, San Francisco" Post-Market Randomized Controlled Trial: Endoscopically- Guided Ablation vs. Radiofrequency Ablation GuideD by Electroanatomical Mapping to Achieve Permanent Pulmonary Vein Isolation (En-GARDE),Device,"Active,Recr |
| Irrigated Ablation System Evaluation for AF(IRASE-AF) (web link) | Device | Enrolling by invitation | Paroxysmal Atrial Fibrillation | SJM Irrigated Cardiac Ablation System | FDA approved Open Irrigated RF Ablation System | St. Jude Medical |
| Effectiveness of Bridging Anticoagulation for Surgery (The BRIDGE Study) (web link) | Drug | Active,Recruiting | Atrial Fibrillation | Dalteparin(Phase III) | Placebo | National Heart, Lung, and Blood Institute (NHLBI)"
Evaluation of Depolarization and Repolarisation Activity During Cardiac Arrhythmia Using a Novel Monophasic Action Potential Catheter,Device,Not yet recruiting,Atrial Fibrillation Ventricular Fibrillatio |
| Detection of Left Atrial Appendage (LAA) Thrombus: Comparison of Cardiac Magnetic Resonance Imaging and Transesophageal Echocardiogram (web link) | Observational | Active,Recruiting | Left Atrial Appendage Thrombi | Observational | NA | Gundersen Lutheran Medical Foundation Gundersen Lutheran Health System |
| Capsule Endoscopy for Post-Ablation Esophageal Lesion Assessment (web link) | Device | Active,Recruiting | Esophageal Lesion | PillCam ESO Capsule Endoscope | NA | The Cleveland Clinic Given Imaging Ltd. |
| Sodium Channel Splicing in Heart Failure Trial(SOCS-HEFT) (web link) | Observational | Active,Recruiting | Atrial Fibrillation Atrial Flutter Heart Failure | Observational | NA | University of Illinois Jesse Brown Veterans Affairs Medical Center |
| The Efficacy and Safety of CARTO 3D Mapping System Versus Conventional Method in AF and VT (web link) | Device | Enrolling by invitation | Atrial Fibrillation | CARTO 3D(Phase IV) | Angiography | Korea University |
| Effect of BMS-914392 on Pharmacokinetics of Metoprolol (web link) | Drug | Active,not Recruiting | Atrial Fibrillation | BMS-914392(Phase I) | metoprolol | Bristol-Myers Squibb PRA International |
| Triple Therapy in Patients on Oral Anticoagulation After Drug Eluting Stent Implantation (web link) | Drug | Active,Recruiting | Coronary Artery Disease Atrial Fibrillation Mechanical Heart Valves | 6 weeks(Phase IV) | 6 months | Deutsches Herzzentrum Muenchen |
| Genomic Investigation of Cardiovascular Diseases (web link) | Observational | Active,not Recruiting | Coronary Artery Disease Myocardial Infarction Atrial Fibrillation Aortic Stenosis Mitral Regurgitation Idiopathic Cardiomyopathy | Observational | NA | Scripps Translational Science Institute |
| Resync-AF (Rate vs Rhythm Control in AF Patients With CRT-D) (web link) | Other | Enrolling by invitation | Atrial Fibrillation | rate control via CRT-D and AVN ablation(Phase IV) | rhythm control via pharmacologic, electrical or ablative therapies | University of Pittsburgh |
| Predictive Genetic Risk Assessment Trial(PGT) (web link) | Genetic | Enrolling by invitation | Colon Cancer Lung Cancer Atrial Fibrillation Diabetes Type 2 Obesity Breast Cancer Graves Disease Osteoarthritis Celiac Disease Myocardial Infarction Prostate Cancer | SNP analysis | NA | Mayo Clinic |
| Safer Warfarin Treatment (web link) | Other | Active,Recruiting | Atrial Fibrillation Venous Thrombosis Pulmonary Embolism Heart Valve Prosthesis | Blood specimens (whole blood, serum, plasma) | NA | Oslo University Hospital Norway: University of Oslo Norway: Norwegian Medicines Agency Norway: South-Eastern Norway Regional Health Authority |
| Personalized Warfarin Dosing by Genomics and Computational Intelligence (web link) | Device | Active,Recruiting | Venous Thrombosis Atrial Fibrillation Myocardial Infarction | Model Predictive Control | NA | Department of Veterans Affairs |
| Randomized Trial of Interventions to Improve Warfarin Adherence (web link) | Behavioural | Active,Recruiting | Atrial Fibrillation Deep Vein Thrombosis Dilated Cardiomyopathies | Financial Incentive and Med-eMonitor|Device: 2Med-eMonitor(Phase III) | NA | University of Pennsylvania |
| VKORC1 and CYP2C9 Gene Polymorphisms and Warfarin Management (web link) | Drug | Active,Recruiting | Atrial Fibrillation Cardiac Thrombus Deep Vein Thrombosis Pulmonary Embolism Heart Valve Replacement (Mechanical or Biological With AF) Cardiomyopathy (Ischemic or Dilated) Peripheral Vascular Disease | Warfarin dose titration | NA | Ankara University |
| Genotype-Guided Warfarin Therapy Trial (web link) | Other | Active,Recruiting | Atrial Fibrillation Deep Vein Thrombosis Pulmonary Embolism Artificial Heart Valve | Genotype-guided dose determination | Non-genotype guided warfarin dosing | University of North Carolina, Chapel Hill UNC Institute for Pharmacogenomics and Individualized Therapy" INFLACOR - Genetic and Physiologic Predictors of Inflammation Related Complications After Heart Surgery,Procedure,"Active,Recruiting |
| European Pharmacogenetics of AntiCoagulant Therapy - Phenprocoumon(EU-PACT) (web link) | Other | Not yet recruiting | Venous Thromboembolism (VTE) Atrial Fibrillation (AF) | Genotype-guided dosing algorithm(Phase IV) | Non-genotype-guided dosing algorithm | Utrecht Institute for Pharmaceutical Sciences Utrecht University Leiden University Medical Center Erasmus Medical Center University of Ulm Newcastle University University of Liverpool LGC Ltd. Hospital Sierrallana Uppsala University Democritus University |
| Examine the Effects of Maintaining Body Core Temperature During CABGs (web link) | Device | Not yet recruiting | Coronary Artery Bypass Grafting | Allon Thermowrap. MTRE Advanced Technologies Ltd. | NA | Centro Cardiologico Monzino |
| Medical Versus Surgical Management of Moderate Mitral Regurgitation Following Percutaneous Coronary Intervention (web link) | Procedure | Active,Recruiting | Myocardial Infarction Mitral Regurgitation | surgical mitral valve repair w/ mitral valve annuloplasty(Phase II) | NA | Southern Illinois University |
| Angiotensin-converting-enzyme (ACE) Inhibitors in Hemodialysis(ARCADIA) (web link) | Drug | Active,Recruiting | Left Ventricular Hypertrophy Hypertension | ACE inhibitor Ramipril(Phase III) | non-RAS inhibitor antihypertensive therapy | Mario Negri Institute for Pharmacological Research Agenzia Italiana del Farmaco |
| AtriCure Exclusion of the LAA in Patients Undergoing Concomitant Cardiac Surgery (web link) | Device | Active,not Recruiting | Left Atrial Appendage Exclusion | AtriCure LAA Exclusion System(Phase II) | NA | AtriCure, Inc"
PREFER (Pacemaker Remote Follow-Up Evaluation and Review),Other,Completed,Bradycardia Arrhythmia,Transtelephonic monitoring (TTM),Medtronic CareLink® Network,Medtronic Cardiac Rhythm Disease Management Medtronic Evaluation of the Cardiobl |
| Transseptal Needle Versus Radiofrequency Energy for Left Atrial Access (web link) | Device | Active,Recruiting | Heart Atria | Radiofrequency energy needle | NA | University of California, San Francisco" Effects Rapid Atrial Pacing Has on the Electrocardiogram (ECG) in Patients With Dual Chamber Pacemakers,Observational,"Active,Recruiting |
| Spontaneous Atrioventricular Conduction Preservation(CAN SAVE R) (web link) | Device | Active,not Recruiting | Patients With Pacemaker With Conduction Problems | Pacing mode(Phase IV) | NA | Montreal Heart Institute Sorin Group Canada |
| Biospecimen Repository for Cardiac Arrhythmias at the Cleveland Clinic (web link) | Observational | Active,Recruiting | Arrhythmias Cardiac | Observational | NA | The Cleveland Clinic |
| Applying Pharmacogenetic Algorithms to Individualize Dosing of Warfarin(COUMAGEN II) (web link) | Genetic | Active,Recruiting | Thromboembolism | IWPC adapted genotype-guided dosing algorithm for warfarin(Phase III) | Modified IWPC genetic-guided warfarin dosing algorithm | Intermountain Health Care, Inc." Study of New Implantable Loop Recorder,Device,"Active,Recruiting |
| The Transendocardial Autologous Cells (hMSC or hBMC) in Ischemic Heart Failure Trial (TAC-HFT) (web link) | Biological | Active,Recruiting | Stem Cell Transplantation Ventricular Dysfunction Left | Autologous human mesenchymal cells (hMSCs)(Phase II) | Placebo | University of Miami |
| The Percutaneous Stem Cell Injection Delivery Effects on Neomyogenesis Pilot Study (The POSEIDON-Pilot Study) (web link) | Biological | Active,Recruiting | Stem Cell Transplantation | Auto-hMSCs(Phase II) | Allo-hMSCs | National Heart, Lung, and Blood Institute (NHLBI) University of Miami" Safety and Effectiveness of Oral Alendronate Therapy on Bone Mineral Density in HIV-infected Children and Adolescents With Low Bone Mineral Density,Drug,"Active,Recruiting |
| Japan Central Aortic Pressure Prospective Study(JCARP) (web link) | Observational | Active,Recruiting | Healthy | Observational | NA | Jichi Medical University |
| Clinical Study Of Eplerenone In Japanese Patients With Chronic Heart Failure (web link) | Drug | Active,Recruiting | Heart Failure | Eplerenone(Phase III) | Placebo | Pfizer |
| Starch or Saline After Cardiac Surgery(SSACS) (web link) | Drug | Active,Recruiting | Coronary Artery Bypass Surgery | 6% Hydroxyethyl Starch 130/0.4 | 0.9% Normal Saline | London Health Sciences Centre |
| Collaborative Systematic Overview of Randomised Controlled Trials of Beta-Blockers in the Treatment of Heart Failure (web link) | Drug | Enrolling by invitation | Heart Failure | Beta blockers | Placebo | Royal Brompton & Harefield NHS Foundation Trust University of Oxford |
| Personalized Dashboard to Educate Veterans at Risk of Stroke (web link) | Behavioural | Active,Recruiting | Cardiovascular Disease Stroke | Risk Factor Counseling | Risk Factor Counseling Plus Computerized Dashboard | Department of Veterans Affairs |
| Effects of Angiotensin II Receptor Blocker Compared With Diuretics in High-risk Hypertensive Patients (web link) | Drug | Active,Recruiting | Essential Hypertension | Amlodipine, Telmisartan, compound Amiloride, Simvastatin(Phase IV) | NA | Cardiovascular Institute & Fuwai Hospital |
| Effect of Preliminary Administration of Cyclosporine (Sandimmun ®) on Different Markers of Cardiac Ischaemia Induced by Cardiopulmonary Bypass (web link) | Drug | Active,Recruiting | Coronary Artery Bypass Surgery Cardiopulmonary Bypass | Sandimmum(Phase II) | Placebo | University Hospital, Grenoble" QuickOptTM Study - Using the QuickOptTM Method for Timing Cycle Optimization,Device,"Active,Recruiting |
| Continuous Positive Airway Pressure Treatment of Obstructive Sleep Apnea to Prevent Cardiovascular Disease(SAVE) (web link) | Device | Active,Recruiting | Sleep Apnea Cardiovascular Disease | Continuous Positive Airway Pressure (CPAP)(Phase III) | Standard care | Adelaide Institute for Sleep Health Respironics ResMed Fisher and Paykel Healthcare The George Institute |
| Optimize RV Follow-up Selective Site Pacing Clinical Trial (web link) | Device | Enrolling by invitation | Cardiac Pacing Artificial Cardiac Pacemaker Artificial | Medtronic or Vitatron Dual-Chamber Pacemaker | Medtronic SelectSecure 3830 Lead | Medtronic Cardiac Rhythm Disease Management |
| Comparison Between Remote Patient Management and Standard Care in CRT-D and ICD-patients to Assess the Impact on Hospital Length of Stay Because of Heart Failure(ConnectOptiVol) (web link) | Behavioural | Active,Recruiting | Heart Failure Ventricular Tachycardia Cardiac Desynchronization | Device triggered remote telephone contact because of Care Alert | Control Arm | Medtronic Bakken Research Center Medtronic |
| Impact Of Eplerenone On Cardiovascular Outcomes In Patients Post Myocardial Infarction (web link) | Drug | Active,Recruiting | Myocardial Infarction | Eplerenone | Placebo | Pfizer |
| Atrial Fibrillation Ablation The Hybrid Approach Versus Traditional Management (AF) (web link) | NA | participant recruitment | Ablation of Atrial Fibrillation | Pulmonary vein isolation ablation procedure for atrial fibrillation (Phase 0) | Hybrid procedure for ablation of atrial fibrillation | Inova Health Care Services |
| Atrial Fibrillation After Cardiac Surgery-comparing Conventional and Miniaturized Bypass Systems (web link) | Procedure | Recruiting | Atrial Fibrillation | Miniaturized bypass system (NA) | NA | Kuopio University Hospital |
| The Assessment of Oxidative Stress Markers and the Development of Atrial Fibrillation After Cardiac Surgery (POAF) (web link) | NA | Recruiting | Atrial Fibrillation | NA (NA) | NA | University of Illinois |
| Dual Epicardial Endocardial Persistent Atrial Fibrillation (AF) Study (DEEP) (web link) | Device | Recruiting | Persistent Atrial Fibrillation or Longstanding Persistent Atrial Fibrillation | Hybrid ablation procedure (Phase I) | NA | AtriCure, Inc |
| Omega-3 Fatty Acids for Prevention of Post-Operative Atrial Fibrillation (OPERA) (web link) | Drug | recruiting | Atrial Fibrillation | Omega -3 fatty acids (Phase III) | Placebo | Brigham and Women's Hospital |
| Node and Atrial Fibrillation Ablation for Persistent Atrial Fibrillation (NAFAPAF) (web link) | Drug | Recruiting | Persistent Atrial Fibrillation | AF ablation and AV node ablation (NA) | AV node ablation | Eastbourne General Hospital |
| Ranolazine for the Prevention of Atrial Fibrillation After Electrical Cardioversion (web link) | Drug | Not yet recruiting | Atrial Fibrillation | Ranolazine (Phase III) | Matching placebo | University of Oklahoma |
| Catheter Ablation Versus Medical Rate Control for Atrial Fibrillation in Patients With Heart Failure (ARC-HF) (web link) | Drug, Procedure | Recruiting | Atrial Fibrillation | Medication to control ventricular rate in AF (NA) | Catheter Ablation for Persistent Atrial Fibrillation | Royal Brompton & Harefield NHS Foundation Trust |
| Benefit of Complex Fractionated Atrial Electrograms Elimination in Atrial Fibrillation Ablation (web link) | Procedure | Recruiting | Atrial Fibrillation Catheter Ablation | Additional Complex Fractionated Electrograms ablation (Phase III) | Standard atrial fibrillation ablation procedure | Hospital Clinic of Barcelona |
| The Use of Statins Following a Left Atrial Catheter Ablation Procedure to Prevent Atrial Fibrillation (web link) | Drug | Active, not recruiting | Atrial Fibrillation Arrhythmia | Atorvistatin (Phase IV) | Placebo | Mayo Clinic |
| Implantable Loop Recorder Versus Conventional Ambulatory Monitoring in Detecting Atrial Fibrillation After Pulmonary Vein Isolation (web link) | Device | Recruiting | Atrial Fibrillation | Implantable loop recorder (ILR) (NA) | NA | Odense University Hospital |
| Pacemaker Holter Assessment of the Effect of BMS-914392 on Atrial Fibrillation Burden (web link) | Drug | Recruiting | Atrial Fibrillation | BMS-914392 (Phase II) | Placebo | Bristol-Myers Squibb |
| First Line Radiofrequency Ablation Versus Antiarrhythmic Drugs for Atrial Fibrillation Treatment (The RAAFT Study) (web link) | Procedure, Drug | Active, not recruiting | Atrial Fibrillation | Pulmonary Vein Isolation performed by Catheter Ablation (Phase III) | Conventional Antiarrhythmic Drug Therapy | Population Health Research Institute |
| The Use of Statins Following a Left Atrial Catheter Ablation Procedure to Prevent Atrial Fibrillation (web link) | Drug | ongoing, not recruiting | Atrial Fibrillation | Atorvistatin (Phase IV) | Placebo | Mayo Clinic |
| Manual Compared to Magnetic Navigation in Ablation for Atrial Fibrillation (web link) | Procedure | Not yet recruiting | Atrial Fibrillation | Magnetic navigation (NA) | Ablation performed with manual navigation | Norwegian University of Science and Technology |
| Identification of Genetic, Biochemical and Hormonal Factors Contributing to Atrial Fibrillation (web link) | NA | Active, not recruiting Atrial Fibrillation | Atrial Fibrillation | NA (NA) | NA | The Cleveland Clinic |
| First Line Radiofrequency Ablation Versus Antiarrhythmic Drugs for Atrial Fibrillation Treatment (The RAAFT Study) (web link) | Procedure, Drug | Active, not recruiting | Atrial Fibrillation | Pulmonary Vein Isolation performed by Catheter Ablation (Phase III) | Conventional Antiarrhythmic Drug Therapy | Population Health Research Institute |
| MINERVA: MINimizE Right Ventricular Pacing to Prevent Atrial Fibrillation and Heart Failure (web link) | Heart Failure, Congestive | Active, not recruiting | Atrial Fibrillation | Pacemaker Medtronic EnRhythm (Phase IV) | NA | Medtronic Bakken Research Center |
| EPLERAF-Study: Eplerenone in the Prevention of Atrial Fibrillation Recurrences After Cardioversion (web link) | Drug | Recruiting | Atrial Fibrillation | Eplerenone (Phase II) | Placebo | University Hospital, Saarland |
| 30-Day Cardiac Event Monitor Belt for Recording Atrial Fibrillation After a Cerebral Ischemic Event (EMBRACE) (web link) | Device | Recruiting | Stroke Transient Ischemic Attack Atrial Fibrillation Atrial Flutter | a 30-day ambulatory cardiac event monitor (NA) | 24-hour Holter | Sunnybrook Health Sciences Centre |
| The Effect of Short Term Amiodarone Treatment After Catheter Ablation for Atrial Fibrillation (AMIO-CAT) (web link) | Drug,Procedure | Recruiting | Atrial Fibrillation | Catheter ablation (NA) | Placebo,Amiodarone | Rigshospitalet, Denmark |
| TOCCASTAR - TactiCath Contact Force Ablation Catheter Study for Atrial Fibrillation (web link) | Procedure | Recruiting | Paroxysmal Atrial Fibrillation | Catheter ablation for the treatment of paroxysmal atrial fibrillation (NA) | NA | Endosense |
| The Dynamics of Human Atrial Fibrillation (web link) | NA | Recruiting | Atrial Fibrillation | NA (NA) | NA | National Heart, Lung, and Blood Institute (NHLBI) |
| Training in Atrial Fibrillation (web link) | Behavioral | Recruiting | Atrial Fibrillation | Interval training (NA) | NA | Norwegian University of Science and Technology |
| Cardioversion vs. Catheter Ablation for Persistent Atrial Fibrillation (web link) | Procedure | Unknown | Atrial Fibrillation | catheter ablation (Phase IV) | external electric cardioversion | Deutsches Herzzentrum Muenchen |
| A Study of the Efficacy and Safety of Vernakalant Hydrochloride (MK-6621) in Patients With Atrial Fibrillation (MK-6621-010 AM2) (web link) | Drug | Recruiting | Atrial Fibrillation | vernakalant hydrochloride (Phase III) | Placebo to vernakalent hydrochloride | Merck |
| Prophylaxis to Reduce Postoperative Atrial Fibrillation in Cardiac Surgery (web link) | Drug | Recruiting | Atrial Fibrillation | beta blockers (Phase III) | amiodarone | Maine Medical Center |